2eu9: Difference between revisions

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-[[Image:2eu9.png|left|200px]]
-{{STRUCTURE_2eu9|  PDB=2eu9  |  SCENE=  }}
+==Crystal Structure of CLK3==
+<StructureSection load='2eu9' size='340' side='right'caption='[[2eu9]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
-===Crystal Structure of CLK3===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2eu9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EU9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EU9 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_19278650}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eu9 OCA], [https://pdbe.org/2eu9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eu9 RCSB], [https://www.ebi.ac.uk/pdbsum/2eu9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eu9 ProSAT]</span></td></tr>
-[[2eu9]] is a 1 chain structure of [[Dual specificity protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EU9 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eu/2eu9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eu9 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Dual specificity protein kinase|Dual specificity protein kinase]]
+*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:019278650</ref><references group="xtra"/>
+__TOC__
-[[Category: Dual-specificity kinase]]
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Aerrowsmith, C.]]
+[[Category: Large Structures]]
-[[Category: Bullock, A.]]
+[[Category: Aerrowsmith C]]
-[[Category: Bunkoczi, G.]]
+[[Category: Bullock A]]
-[[Category: Das, S.]]
+[[Category: Bunkoczi G]]
-[[Category: Delft, F von.]]
+[[Category: Das S]]
-[[Category: Edwards, A.]]
+[[Category: Edwards A]]
-[[Category: Fedorov, O.]]
+[[Category: Fedorov O]]
-[[Category: Gileadi, C.]]
+[[Category: Gileadi C]]
-[[Category: Knapp, S.]]
+[[Category: Knapp S]]
-[[Category: Papagrigoriou, E.]]
+[[Category: Papagrigoriou E]]
-[[Category: Rellos, P.]]
+[[Category: Rellos P]]
-[[Category: Savitsky, P.]]
+[[Category: Savitsky P]]
-[[Category: Sobott, F.]]
+[[Category: Sobott F]]
-[[Category: Sundstrom, M.]]
+[[Category: Sundstrom M]]
-[[Category: Turnbull, A.]]
+[[Category: Turnbull A]]
-[[Category: Ugochukwu, E.]]
+[[Category: Ugochukwu E]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt J]]
-[[Category: Kinase domain]]
+[[Category: Von Delft F]]
-[[Category: Transferase]]