2eta: Difference between revisions

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-[[Image:2eta.png|left|200px]]
-{{STRUCTURE_2eta|  PDB=2eta  |  SCENE=  }}
+==Crystal structure of the ankyrin repeat domain of the TRPV2==
+<StructureSection load='2eta' size='340' side='right'caption='[[2eta]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2eta]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ETA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ETA FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eta OCA], [https://pdbe.org/2eta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eta RCSB], [https://www.ebi.ac.uk/pdbsum/2eta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eta ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TRPV2_RAT TRPV2_RAT] Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity).<ref>PMID:10201375</ref> <ref>PMID:15249591</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/et/2eta_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eta ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of the ankyrin repeat domain of the TRPV2===
+==See Also==
+*[[Ion channels 3D structures|Ion channels 3D structures]]
-{{ABSTRACT_PUBMED_16809337}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[2eta]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ETA OCA].
+</StructureSection>
+[[Category: Large Structures]]
-==Reference==
-<ref group="xtra">PMID:016809337</ref><references group="xtra"/>
 [[Category: Rattus norvegicus]]
-[[Category: Gaudet, R.]]
+[[Category: Gaudet R]]
-[[Category: Jin, X.]]
+[[Category: Jin X]]
-[[Category: Ankyrin repeat domain]]
-[[Category: Transport protein]]
-[[Category: Trpv2]]