2et6: Difference between revisions

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[[Image:2et6.png|left|200px]]


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==(3R)-Hydroxyacyl-CoA Dehydrogenase Domain of Candida tropicalis Peroxisomal Multifunctional Enzyme Type 2==
The line below this paragraph, containing "STRUCTURE_2et6", creates the "Structure Box" on the page.
<StructureSection load='2et6' size='340' side='right'caption='[[2et6]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2et6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_tropicalis Candida tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ET6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ET6 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2et6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2et6 OCA], [https://pdbe.org/2et6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2et6 RCSB], [https://www.ebi.ac.uk/pdbsum/2et6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2et6 ProSAT]</span></td></tr>
{{STRUCTURE_2et6| PDB=2et6 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/FOX2_CANTR FOX2_CANTR] Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/et/2et6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2et6 ConSurf].
<div style="clear:both"></div>


===(3R)-Hydroxyacyl-CoA Dehydrogenase Domain of Candida tropicalis Peroxisomal Multifunctional Enzyme Type 2===
==See Also==
 
*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
 
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{{ABSTRACT_PUBMED_16574148}}
 
==About this Structure==
2ET6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Candida_tropicalis Candida tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ET6 OCA].
 
==Reference==
Crystal structure of yeast peroxisomal multifunctional enzyme: structural basis for substrate specificity of (3R)-hydroxyacyl-CoA dehydrogenase units., Ylianttila MS, Pursiainen NV, Haapalainen AM, Juffer AH, Poirier Y, Hiltunen JK, Glumoff T, J Mol Biol. 2006 May 19;358(5):1286-95. Epub 2006 Mar 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16574148 16574148]
[[Category: Candida tropicalis]]
[[Category: Candida tropicalis]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Glumoff, T.]]
[[Category: Glumoff T]]
[[Category: Hiltunen, J K.]]
[[Category: Hiltunen JK]]
[[Category: Ylianttila, M S.]]
[[Category: Ylianttila MS]]
[[Category: Beta-oxidation]]
[[Category: Dehydrogenase]]
[[Category: Mfe-2]]
[[Category: Oxidoreductase]]
[[Category: Peroxisome]]
[[Category: Sdr]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:13:06 2008''

Latest revision as of 12:19, 14 February 2024

(3R)-Hydroxyacyl-CoA Dehydrogenase Domain of Candida tropicalis Peroxisomal Multifunctional Enzyme Type 2(3R)-Hydroxyacyl-CoA Dehydrogenase Domain of Candida tropicalis Peroxisomal Multifunctional Enzyme Type 2

Structural highlights

2et6 is a 1 chain structure with sequence from Candida tropicalis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.22Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FOX2_CANTR Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2et6, resolution 2.22Å

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