2cse: Difference between revisions

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-{{Seed}}
-[[Image:2cse.png|left|200px]]
-<!--
+==Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image Reconstruction of the virion at 7.0-A Resolution==
-The line below this paragraph, containing "STRUCTURE_2cse", creates the "Structure Box" on the page.
+<SX load='2cse' size='340' side='right' viewer='molstar' caption='[[2cse]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2cse]] is a 27 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_1_Lang Mammalian orthoreovirus 1 Lang] and [https://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3_Dearing Mammalian orthoreovirus 3 Dearing]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CSE FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cse OCA], [https://pdbe.org/2cse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cse RCSB], [https://www.ebi.ac.uk/pdbsum/2cse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cse ProSAT]</span></td></tr>
-{{STRUCTURE_2cse|  PDB=2cse  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MU1_REOVL MU1_REOVL] Major outer capsid protein involved in host cell membrane penetration. In the endocytic compartment, outer-capsid protein sigma-3 is removed by cathepsin proteases, which exposes the viral membrane-penetration protein mu-1. Both myristoylated peptides mu-1N and phi are released during infectious subvirion particles (ISVP) formation in the endosome. They associate with host membranes and mu-1N induces permeabilization and delivery of transcriptionally active viral particles into the host cell cytoplasm. Seems to induce apoptosis in the host cell.<ref>PMID:11007773</ref> <ref>PMID:15280481</ref> <ref>PMID:16912293</ref> <ref>PMID:17005655</ref> <ref>PMID:18369316</ref>   The viral outer shell polypeptides, of which mu-1 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3.<ref>PMID:11007773</ref> <ref>PMID:15280481</ref> <ref>PMID:16912293</ref> <ref>PMID:17005655</ref> <ref>PMID:18369316</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/2cse_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cse ConSurf].
+<div style="clear:both"></div>
-===Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image Reconstruction of the virion at 7.0-A Resolution===
+==See Also==
+*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_16216585}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 16216585 is the PubMed ID number.
+</SX>
--->
+[[Category: Large Structures]]
-{{ABSTRACT_PUBMED_16216585}}
+[[Category: Mammalian orthoreovirus 1 Lang]]
+[[Category: Mammalian orthoreovirus 3 Dearing]]
-==About this Structure==
+[[Category: Baker TS]]
-CSE is a 27 chains structure of sequences from [http://en.wikipedia.org/wiki/Mammalian_orthoreovirus_1 Mammalian orthoreovirus 1] and [http://en.wikipedia.org/wiki/Mammalian_orthoreovirus_3 Mammalian orthoreovirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CSE OCA].
+[[Category: Harrison SC]]
+[[Category: Ji Y]]
-==Reference==
+[[Category: Marinescu DC]]
-<ref group="xtra">PMID:16216585</ref><references group="xtra"/>
+[[Category: Nibert ML]]
-[[Category: Mammalian orthoreovirus 1]]
+[[Category: Zhang L]]
-[[Category: Mammalian orthoreovirus 3]]
+[[Category: Zhang X]]
-[[Category: Baker, T S.]]
-[[Category: Harrison, S C.]]
-[[Category: Ji, Y.]]
-[[Category: Marinescu, D C.]]
-[[Category: Nibert, M L.]]
-[[Category: Zhang, L.]]
-[[Category: Zhang, X.]]
-[[Category: Cryoem]]
-[[Category: Icosahedral virus]]
-[[Category: Image processing]]
-[[Category: Membrane penetration protein]]
-[[Category: Reovirus]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:11:41 2009''