2aty: Difference between revisions

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-{{Seed}}
-[[Image:2aty.png|left|200px]]
-<!--
+==Complement receptor chimaeric conjugate CR2-Ig==
-The line below this paragraph, containing "STRUCTURE_2aty", creates the "Structure Box" on the page.
+<StructureSection load='2aty' size='340' side='right'caption='[[2aty]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2aty]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ATY FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aty OCA], [https://pdbe.org/2aty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aty RCSB], [https://www.ebi.ac.uk/pdbsum/2aty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aty ProSAT]</span></td></tr>
-{{STRUCTURE_2aty|  PDB=2aty  |  SCENE=  }}
+</table>
+== Disease ==
-===Complement receptor chimaeric conjugate CR2-Ig===
+[https://www.uniprot.org/uniprot/CR2_HUMAN CR2_HUMAN] Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) [MIM:[https://omim.org/entry/610927 610927]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:17360460</ref>   Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7) [MIM:[https://omim.org/entry/614699 614699]. A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.<ref>PMID:22035880</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/CR2_HUMAN CR2_HUMAN] Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation.<ref>PMID:7753047</ref> [https://www.uniprot.org/uniprot/IGHG1_MOUSE IGHG1_MOUSE]
-<!--
+== Evolutionary Conservation ==
-The line below this paragraph, {{ABSTRACT_PUBMED_16375923}}, adds the Publication Abstract to the page
+[[Image:Consurf_key_small.gif|200px|right]]
-(as it appears on PubMed at http://www.pubmed.gov), where 16375923 is the PubMed ID number.
+Check<jmol>
--->
+  <jmolCheckbox>
-{{ABSTRACT_PUBMED_16375923}}
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/at/2aty_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-==About this Structure==
+    <text>to colour the structure by Evolutionary Conservation</text>
-ATY is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens,_mus_musculus Homo sapiens, mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ATY OCA].
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aty ConSurf].
-==Reference==
+<div style="clear:both"></div>
-<ref group="xtra">PMID:16375923</ref><references group="xtra"/>
+== References ==
-[[Category: Homo sapiens, mus musculus]]
+<references/>
-[[Category: Aslam, M.]]
+__TOC__
-[[Category: Gilbert, H E.]]
+</StructureSection>
-[[Category: Guthridge, J M.]]
+[[Category: Homo sapiens]]
-[[Category: Holers, V M.]]
+[[Category: Large Structures]]
-[[Category: Perkins, S J.]]
+[[Category: Mus musculus]]
-[[Category: Antibody]]
+[[Category: Aslam M]]
-[[Category: Complement]]
+[[Category: Gilbert HE]]
-[[Category: Immunoglobulin fold]]
+[[Category: Guthridge JM]]
+[[Category: Holers VM]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 12:42:42 2009''
+[[Category: Perkins SJ]]