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[[Image:2asl.png|left|200px]]


{{STRUCTURE_2asl|  PDB=2asl  |  SCENE=  }}
==oxoG-modified Postinsertion Binary Complex==
 
<StructureSection load='2asl' size='340' side='right'caption='[[2asl]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
===oxoG-modified Postinsertion Binary Complex===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2asl]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ASL FirstGlance]. <br>
{{ABSTRACT_PUBMED_16379496}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2asl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asl OCA], [https://pdbe.org/2asl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2asl RCSB], [https://www.ebi.ac.uk/pdbsum/2asl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2asl ProSAT]</span></td></tr>
[[2asl]] is a 6 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASL OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPO4_SACS2 DPO4_SACS2] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/2asl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2asl ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[DNA polymerase|DNA polymerase]]
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:016379496</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: DNA-directed DNA polymerase]]
[[Category: Saccharolobus solfataricus]]
[[Category: Sulfolobus solfataricus]]
[[Category: Broyde S]]
[[Category: Broyde, S.]]
[[Category: Cheng Y]]
[[Category: Cheng, Y.]]
[[Category: Geacintov NE]]
[[Category: Geacintov, N E.]]
[[Category: Kuryavyi V]]
[[Category: Kuryavyi, V.]]
[[Category: Malinina L]]
[[Category: Malinina, L.]]
[[Category: Patel DJ]]
[[Category: Patel, D J.]]
[[Category: Rechkoblit O]]
[[Category: Rechkoblit, O.]]
[[Category: 8-oxoguanine]]
[[Category: Dna polymerase]]
[[Category: Lesion bypass]]
[[Category: Transferase-dna complex]]
[[Category: Y-family]]

Latest revision as of 12:14, 14 February 2024

oxoG-modified Postinsertion Binary ComplexoxoG-modified Postinsertion Binary Complex

Structural highlights

2asl is a 6 chain structure with sequence from Saccharolobus solfataricus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.65Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DPO4_SACS2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2asl, resolution 2.65Å

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OCA
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