2ano: Difference between revisions

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-[[Image:2ano.png|left|200px]]
-{{STRUCTURE_2ano|  PDB=2ano  |  SCENE=  }}
+==Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17==
+<StructureSection load='2ano' size='340' side='right'caption='[[2ano]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
-===Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ano]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ANO FirstGlance]. <br>
-{{ABSTRACT_PUBMED_17125251}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=817:1-{[N-(1-IMINO-GUANIDINO-METHYL)]SULFANYLMETHYL}-3-TRIFLUOROMETHYL-BENZENE'>817</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ano FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ano OCA], [https://pdbe.org/2ano PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ano RCSB], [https://www.ebi.ac.uk/pdbsum/2ano PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ano ProSAT]</span></td></tr>
-[[2ano]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANO OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/2ano_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ano ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Dihydrofolate reductase|Dihydrofolate reductase]]
+*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:017125251</ref><ref group="xtra">PMID:016126221</ref><references group="xtra"/>
-[[Category: Dihydrofolate reductase]]
 [[Category: Escherichia coli]]
-[[Category: Brown, E D.]]
+[[Category: Large Structures]]
-[[Category: Daigle, D M.]]
+[[Category: Brown ED]]
-[[Category: Hughes, D W.]]
+[[Category: Daigle DM]]
-[[Category: Jackson, S G.]]
+[[Category: Hughes DW]]
-[[Category: Junop, M S.]]
+[[Category: Jackson SG]]
-[[Category: Mayer, S.]]
+[[Category: Junop MS]]
-[[Category: Organ, M.]]
+[[Category: Mayer S]]
-[[Category: Summerfield, R L.]]
+[[Category: Organ M]]
-[[Category: Dhfr]]
+[[Category: Summerfield RL]]
-[[Category: Oxidoreductase]]
-[[Category: Protein inhibitor complex]]