2ai7: Difference between revisions

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[[Image:2ai7.png|left|200px]]


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==S.pneumoniae Polypeptide Deformylase complexed with SB-485345==
The line below this paragraph, containing "STRUCTURE_2ai7", creates the "Structure Box" on the page.
<StructureSection load='2ai7' size='340' side='right'caption='[[2ai7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ai7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AI7 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SB7:[HYDROXY(3-PHENYLPROPYL)AMINO]METHANOL'>SB7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_2ai7|  PDB=2ai7  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ai7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ai7 OCA], [https://pdbe.org/2ai7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ai7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ai7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ai7 ProSAT]</span></td></tr>
 
</table>
===S.pneumoniae Polypeptide Deformylase complexed with SB-485345===
== Function ==
 
[https://www.uniprot.org/uniprot/DEF_STRR6 DEF_STRR6] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/2ai7_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_12538898}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2AI7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AI7 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ai7 ConSurf].
 
<div style="clear:both"></div>
==Reference==
__TOC__
<ref group="xtra">PMID:12538898</ref><references group="xtra"/>
</StructureSection>
[[Category: Peptide deformylase]]
[[Category: Large Structures]]
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
[[Category: Aubart, K.]]
[[Category: Aubart K]]
[[Category: Christensen, S B.]]
[[Category: Christensen SB]]
[[Category: Fosberry, A.]]
[[Category: Fosberry A]]
[[Category: Jones, J.]]
[[Category: Jones J]]
[[Category: Lewis, C.]]
[[Category: Lewis C]]
[[Category: Lonetto, M.]]
[[Category: Lonetto M]]
[[Category: McManus, E.]]
[[Category: McManus E]]
[[Category: Petit, C M.]]
[[Category: Petit CM]]
[[Category: Smith, K J.]]
[[Category: Smith KJ]]
[[Category: Smyth, M.]]
[[Category: Smyth M]]
[[Category: Hydrolase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:09:16 2009''

Latest revision as of 12:13, 14 February 2024

S.pneumoniae Polypeptide Deformylase complexed with SB-485345S.pneumoniae Polypeptide Deformylase complexed with SB-485345

Structural highlights

2ai7 is a 1 chain structure with sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DEF_STRR6 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2ai7, resolution 2.00Å

Drag the structure with the mouse to rotate

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OCA
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