2ai7: Difference between revisions

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-[[Image:2ai7.png|left|200px]]
-{{STRUCTURE_2ai7|  PDB=2ai7  |  SCENE=  }}
+==S.pneumoniae Polypeptide Deformylase complexed with SB-485345==
+<StructureSection load='2ai7' size='340' side='right'caption='[[2ai7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-===S.pneumoniae Polypeptide Deformylase complexed with SB-485345===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ai7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AI7 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_12538898}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SB7:[HYDROXY(3-PHENYLPROPYL)AMINO]METHANOL'>SB7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ai7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ai7 OCA], [https://pdbe.org/2ai7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ai7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ai7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ai7 ProSAT]</span></td></tr>
-[[2ai7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AI7 OCA].
+</table>
+== Function ==
-==Reference==
+[https://www.uniprot.org/uniprot/DEF_STRR6 DEF_STRR6] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
-<ref group="xtra">PMID:012538898</ref><references group="xtra"/>
+== Evolutionary Conservation ==
-[[Category: Peptide deformylase]]
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/2ai7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ai7 ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Streptococcus pneumoniae]]
-[[Category: Aubart, K.]]
+[[Category: Aubart K]]
-[[Category: Christensen, S B.]]
+[[Category: Christensen SB]]
-[[Category: Fosberry, A.]]
+[[Category: Fosberry A]]
-[[Category: Jones, J.]]
+[[Category: Jones J]]
-[[Category: Lewis, C.]]
+[[Category: Lewis C]]
-[[Category: Lonetto, M.]]
+[[Category: Lonetto M]]
-[[Category: McManus, E.]]
+[[Category: McManus E]]
-[[Category: Petit, C M.]]
+[[Category: Petit CM]]
-[[Category: Smith, K J.]]
+[[Category: Smith KJ]]
-[[Category: Smyth, M.]]
+[[Category: Smyth M]]
-[[Category: Hydrolase]]