2a7s: Difference between revisions

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-[[Image:2a7s.png|left|200px]]
-{{STRUCTURE_2a7s|  PDB=2a7s  |  SCENE=  }}
+==Crystal Structure of the Acyl-CoA Carboxylase, AccD5, from Mycobacterium tuberculosis==
+<StructureSection load='2a7s' size='340' side='right'caption='[[2a7s]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-===Crystal Structure of the Acyl-CoA Carboxylase, AccD5, from Mycobacterium tuberculosis===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2a7s]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A7S FirstGlance]. <br>
-{{ABSTRACT_PUBMED_16492739}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a7s OCA], [https://pdbe.org/2a7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a7s RCSB], [https://www.ebi.ac.uk/pdbsum/2a7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a7s ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[2a7s]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A7S OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/ACCD5_MYCTU ACCD5_MYCTU] Component of a biotin-dependent acyl-CoA carboxylase complex. This subunit transfers the CO2 from carboxybiotin to the CoA ester substrate (PubMed:16354663, PubMed:16385038, PubMed:28222482). When associated with the alpha3 subunit AccA3, is involved in the carboxylation of acetyl-CoA and propionyl-CoA, with a preference for propionyl-CoA (PubMed:16354663, PubMed:16385038, PubMed:28222482). Is also required for the activity of the long-chain acyl-CoA carboxylase (LCC) complex (PubMed:28222482).<ref>PMID:16354663</ref> <ref>PMID:16385038</ref> <ref>PMID:28222482</ref>
-==Reference==
+== Evolutionary Conservation ==
-<ref group="xtra">PMID:016492739</ref><references group="xtra"/>
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a7/2a7s_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a7s ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mycobacterium tuberculosis]]
-[[Category: Propionyl-CoA carboxylase]]
+[[Category: Lin T]]
-[[Category: Lin, T.]]
+[[Category: Melgar M]]
-[[Category: Melgar, M.]]
+[[Category: Purdon J]]
-[[Category: Purdon, J.]]
+[[Category: Tsai SC]]
-[[Category: Tsai, S C.]]
+[[Category: Tseng T]]
-[[Category: Tseng, T.]]
-[[Category: Acetyl-coa carboxylase]]
-[[Category: Acyl-coa carboxylase]]
-[[Category: Carboxylase]]
-[[Category: Carboxyltransferase]]
-[[Category: Fatty acid]]
-[[Category: Ligase]]
-[[Category: Mycolic acid]]
-[[Category: Polyketide]]
-[[Category: Propionyl-coa carboxylase]]