2a5y: Difference between revisions

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-[[Image:2a5y.png|left|200px]]
-{{STRUCTURE_2a5y|  PDB=2a5y  |  SCENE=  }}
+==Structure of a CED-4/CED-9 complex==
+<StructureSection load='2a5y' size='340' side='right'caption='[[2a5y]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-===Structure of a CED-4/CED-9 complex===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2a5y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. The September 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Apoptosomes''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_9 10.2210/rcsb_pdb/mom_2014_9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A5Y FirstGlance]. <br>
-{{ABSTRACT_PUBMED_16208361}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a5y OCA], [https://pdbe.org/2a5y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a5y RCSB], [https://www.ebi.ac.uk/pdbsum/2a5y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a5y ProSAT]</span></td></tr>
-[[2a5y]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5Y OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CED9_CAEEL CED9_CAEEL] Plays a major role in programmed cell death (PCD, apoptosis). Egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3.<ref>PMID:7907274</ref> <ref>PMID:9024666</ref> <ref>PMID:9027313</ref> <ref>PMID:9604928</ref> <ref>PMID:10688797</ref> <ref>PMID:15383288</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a5/2a5y_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a5y ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Cell death protein|Cell death protein]]
+*[[Cell death protein 3D structures|Cell death protein 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:016208361</ref><ref group="xtra">PMID:020844150</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
+[[Category: Apoptosomes]]
 [[Category: Caenorhabditis elegans]]
-[[Category: Gu, L.]]
+[[Category: Large Structures]]
-[[Category: Hao, Q.]]
+[[Category: RCSB PDB Molecule of the Month]]
-[[Category: Liu, Q.]]
+[[Category: Gu L]]
-[[Category: Shi, Y.]]
+[[Category: Hao Q]]
-[[Category: Yan, N.]]
+[[Category: Liu Q]]
-[[Category: Apoptosis]]
+[[Category: Shi Y]]
-[[Category: Ced-3 activation]]
+[[Category: Yan N]]
-[[Category: Ced-4]]
-[[Category: Ced-9]]