2a07: Difference between revisions
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== | ==Crystal Structure of Foxp2 bound Specifically to DNA.== | ||
[[2a07]] is a 10 chain structure with sequence from [ | <StructureSection load='2a07' size='340' side='right'caption='[[2a07]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2a07]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A07 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a07 OCA], [https://pdbe.org/2a07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a07 RCSB], [https://www.ebi.ac.uk/pdbsum/2a07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a07 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/FOXP2_HUMAN FOXP2_HUMAN] Defects in FOXP2 are the cause of speech-language disorder 1 (SPCH1) [MIM:[https://omim.org/entry/602081 602081]; also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Affected individuals have a severe impairment in the selection and sequencing of fine orofacial movements, which are necessary for articulation. They also show deficits in several facets of language processing (such as the ability to break up words into their constituent phonemes) and grammatical skills.<ref>PMID:11586359</ref> Note=A chromosomal aberration involving FOXP2 is a cause of severe speech and language impairment. Translocation t(5;7)(q22;q31.2). | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FOXP2_HUMAN FOXP2_HUMAN] Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a0/2a07_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a07 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[ | *[[FOX 3D structures|FOX 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | |||
== | </StructureSection> | ||
< | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bates | [[Category: Large Structures]] | ||
[[Category: Chen | [[Category: Bates DL]] | ||
[[Category: Han | [[Category: Chen L]] | ||
[[Category: Nowick | [[Category: Han A]] | ||
[[Category: Paabo | [[Category: Nowick K]] | ||
[[Category: Stroud | [[Category: Paabo S]] | ||
[[Category: Tong | [[Category: Stroud JC]] | ||
[[Category: Wu | [[Category: Tong H]] | ||
[[Category: Wu Y]] | |||
Latest revision as of 12:10, 14 February 2024
Crystal Structure of Foxp2 bound Specifically to DNA.Crystal Structure of Foxp2 bound Specifically to DNA.
Structural highlights
DiseaseFOXP2_HUMAN Defects in FOXP2 are the cause of speech-language disorder 1 (SPCH1) [MIM:602081; also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Affected individuals have a severe impairment in the selection and sequencing of fine orofacial movements, which are necessary for articulation. They also show deficits in several facets of language processing (such as the ability to break up words into their constituent phonemes) and grammatical skills.[1] Note=A chromosomal aberration involving FOXP2 is a cause of severe speech and language impairment. Translocation t(5;7)(q22;q31.2). FunctionFOXP2_HUMAN Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See AlsoReferences
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