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| [[Image:237d.jpg|left|200px]]
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| {{Structure
| | ==CRYSTAL STRUCTURE OF A DNA DECAMER SHOWING A NOVEL PSEUDO FOUR-WAY HELIX-HELIX JUNCTION== |
| |PDB= 237d |SIZE=350|CAPTION= <scene name='initialview01'>237d</scene>, resolution 2.500Å
| | <StructureSection load='237d' size='340' side='right'caption='[[237d]], [[Resolution|resolution]] 2.50Å' scene=''> |
| |SITE=
| | == Structural highlights == |
| |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>
| | <table><tr><td colspan='2'>[[237d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=237D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=237D FirstGlance]. <br> |
| |ACTIVITY=
| | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| |GENE=
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=237d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=237d OCA], [https://pdbe.org/237d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=237d RCSB], [https://www.ebi.ac.uk/pdbsum/237d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=237d ProSAT]</span></td></tr> |
| |DOMAIN=
| | </table> |
| |RELATEDENTRY=
| | __TOC__ |
| |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=237d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=237d OCA], [http://www.ebi.ac.uk/pdbsum/237d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=237d RCSB]</span>
| | </StructureSection> |
| }}
| | [[Category: Large Structures]] |
| | | [[Category: Berman HM]] |
| '''CRYSTAL STRUCTURE OF A DNA DECAMER SHOWING A NOVEL PSEUDO FOUR-WAY HELIX-HELIX JUNCTION'''
| | [[Category: Neidle S]] |
| | | [[Category: Nunn CM]] |
| | | [[Category: Spink N]] |
| ==Overview==
| | [[Category: Vojtechovsky J]] |
| The crystal structure of the decanucleotide d(CGCAATTGCG)2 has been solved by a combination of molecular replacement and heavy-atom procedures and has been refined to an R factor of 20.2% at 2.7 A. It is not a fully base-paired duplex but has a central core of eight Watson-Crick base pairs flanked by unpaired terminal guanosines and cytosines. These participate in hydrogen-bonding arrangements with adjacent decamer duplexes in the crystal lattice. The unpaired guanosines are bound in the G+C regions of duplex minor grooves. The cytosines have relatively high mobility, even though they are constrained to be in one region where they are involved in base-paired triplets with G.C base pairs. The 5'-AATT sequence in the duplex region has a narrow minor groove, providing further confirmation of the sequence-dependent nature of groove width.
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| ==About this Structure==
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| 237D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=237D OCA].
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| ==Reference==
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| Crystal structure of a DNA decamer showing a novel pseudo four-way helix-helix junction., Spink N, Nunn CM, Vojtechovsky J, Berman HM, Neidle S, Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10767-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7479880 7479880]
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| [[Category: Protein complex]] | |
| [[Category: Berman, H M.]] | |
| [[Category: Neidle, S.]] | |
| [[Category: Nunn, C M.]] | |
| [[Category: Spink, N.]] | |
| [[Category: Vojtechovsky, J.]] | |
| [[Category: b-dna]]
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| [[Category: double helix]]
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| [[Category: flipped-out base]]
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| [[Category: intermolecular base triplet]]
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:44:56 2008''
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