1zq9: Difference between revisions

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[[Image:1zq9.png|left|200px]]


{{STRUCTURE_1zq9|  PDB=1zq9  |  SCENE=  }}
==Crystal structure of human Dimethyladenosine transferase==
 
<StructureSection load='1zq9' size='340' side='right'caption='[[1zq9]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===Crystal structure of human Dimethyladenosine transferase===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1zq9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZQ9 FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
[[1zq9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQ9 OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zq9 OCA], [https://pdbe.org/1zq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zq9 RCSB], [https://www.ebi.ac.uk/pdbsum/1zq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zq9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DIM1_HUMAN DIM1_HUMAN] Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604).<ref>PMID:25851604</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zq/1zq9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zq9 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C.]]
[[Category: Large Structures]]
[[Category: Bochkarev, A.]]
[[Category: Arrowsmith C]]
[[Category: Dong, A.]]
[[Category: Bochkarev A]]
[[Category: Edwards, A.]]
[[Category: Dong A]]
[[Category: Loppnau, P.]]
[[Category: Edwards A]]
[[Category: Plotnikov, A.]]
[[Category: Loppnau P]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Plotnikov A]]
[[Category: Sundstrom, M.]]
[[Category: Sundstrom M]]
[[Category: Wu, H.]]
[[Category: Wu H]]
[[Category: Zeng, H.]]
[[Category: Zeng H]]
[[Category: Dimethyladenosine transferase]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]

Latest revision as of 12:06, 14 February 2024

Crystal structure of human Dimethyladenosine transferaseCrystal structure of human Dimethyladenosine transferase

Structural highlights

1zq9 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DIM1_HUMAN Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Zorbas C, Nicolas E, Wacheul L, Huvelle E, Heurgue-Hamard V, Lafontaine DL. The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis. Mol Biol Cell. 2015 Jun 1;26(11):2080-95. doi: 10.1091/mbc.E15-02-0073. Epub 2015, Apr 7. PMID:25851604 doi:http://dx.doi.org/10.1091/mbc.E15-02-0073

1zq9, resolution 1.90Å

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OCA
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