1yvr: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
New page: left|200px<br /><applet load="1yvr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yvr, resolution 1.95Å" /> '''Ro autoantigen'''<br...
 
No edit summary
 
(15 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1yvr.gif|left|200px]]<br /><applet load="1yvr" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1yvr, resolution 1.95&Aring;" />
'''Ro autoantigen'''<br />


==Overview==
==Ro autoantigen==
The Ro 60 kDa autoantigen is a major target of the immune response in, patients with systemic lupus erythematosus. In vertebrate cells, Ro binds, misfolded small RNAs and likely functions in RNA quality control. In, eukaryotes and bacteria, Ro also associates with small RNAs called Y RNAs., We present structures of unliganded Ro and Ro complexed with two RNAs at, 1.95 and 2.2 A resolution, respectively. Ro consists of a von Willebrand, factor A domain and a doughnut-shaped domain composed of HEAT repeats. In, the complex, a fragment of Y RNA binds on the outer surface of the, HEAT-repeat ring, and single-stranded RNA binds in the toroid hole., Mutagenesis supports a binding site for misfolded RNAs that encompasses, both sites, with a single-stranded end inserted into the toroid cavity., Our experiments suggest that one role of Y RNAs may be to regulate access, of other RNAs to Ro.
<StructureSection load='1yvr' size='340' side='right'caption='[[1yvr]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1yvr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YVR FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvr OCA], [https://pdbe.org/1yvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yvr RCSB], [https://www.ebi.ac.uk/pdbsum/1yvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yvr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RO60_XENLA RO60_XENLA] RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation. May play roles in cilia formation and/or maintenance (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yv/1yvr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yvr ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1YVR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1YVR OCA].
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity., Stein AJ, Fuchs G, Fu C, Wolin SL, Reinisch KM, Cell. 2005 May 20;121(4):529-39. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15907467 15907467]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
[[Category: Fu, C.]]
[[Category: Fu C]]
[[Category: Fuchs, G.]]
[[Category: Fuchs G]]
[[Category: Reinisch, K.M.]]
[[Category: Reinisch KM]]
[[Category: Stein, A.J.]]
[[Category: Stein AJ]]
[[Category: Wolin, S.L.]]
[[Category: Wolin SL]]
[[Category: heat repeat; von willebrand factor a; rossmann fold; midas motif']]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 07:05:14 2007''

Latest revision as of 12:00, 14 February 2024

Ro autoantigenRo autoantigen

Structural highlights

1yvr is a 1 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RO60_XENLA RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation. May play roles in cilia formation and/or maintenance (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1yvr, resolution 1.95Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=1yvr&oldid=4056945"