1yvr: Difference between revisions

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-[[Image:1yvr.gif|left|200px]]
- {{Structure
+==Ro autoantigen==
-|PDB= 1yvr |SIZE=350|CAPTION= <scene name='initialview01'>1yvr</scene>, resolution 1.95&Aring;
+<StructureSection load='1yvr' size='340' side='right'caption='[[1yvr]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[1yvr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YVR FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yvr OCA], [https://pdbe.org/1yvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yvr RCSB], [https://www.ebi.ac.uk/pdbsum/1yvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yvr ProSAT]</span></td></tr>
-}}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RO60_XENLA RO60_XENLA] RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation.  May play roles in cilia formation and/or maintenance (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yv/1yvr_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yvr ConSurf].
+<div style="clear:both"></div>
-'''Ro autoantigen'''
+==See Also==
+*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
+__TOC__
-==Overview==
+</StructureSection>
-The Ro 60 kDa autoantigen is a major target of the immune response in patients with systemic lupus erythematosus. In vertebrate cells, Ro binds misfolded small RNAs and likely functions in RNA quality control. In eukaryotes and bacteria, Ro also associates with small RNAs called Y RNAs. We present structures of unliganded Ro and Ro complexed with two RNAs at 1.95 and 2.2 A resolution, respectively. Ro consists of a von Willebrand factor A domain and a doughnut-shaped domain composed of HEAT repeats. In the complex, a fragment of Y RNA binds on the outer surface of the HEAT-repeat ring, and single-stranded RNA binds in the toroid hole. Mutagenesis supports a binding site for misfolded RNAs that encompasses both sites, with a single-stranded end inserted into the toroid cavity. Our experiments suggest that one role of Y RNAs may be to regulate access of other RNAs to Ro.
+[[Category: Large Structures]]
-==About this Structure==
-YVR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YVR OCA].
-==Reference==
-Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity., Stein AJ, Fuchs G, Fu C, Wolin SL, Reinisch KM, Cell. 2005 May 20;121(4):529-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15907467 15907467]
-[[Category: Single protein]]
 [[Category: Xenopus laevis]]
-[[Category: Fu, C.]]
+[[Category: Fu C]]
-[[Category: Fuchs, G.]]
+[[Category: Fuchs G]]
-[[Category: Reinisch, K M.]]
+[[Category: Reinisch KM]]
-[[Category: Stein, A J.]]
+[[Category: Stein AJ]]
-[[Category: Wolin, S L.]]
+[[Category: Wolin SL]]
-[[Category: heat repeat; von willebrand factor a; rossmann fold; midas motifs']]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:28:08 2008''