1yb1: Difference between revisions
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New page: left|200px<br /> <applet load="1yb1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yb1, resolution 1.95Å" /> '''Crystal structure o... |
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== | ==Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI== | ||
<StructureSection load='1yb1' size='340' side='right'caption='[[1yb1]], [[Resolution|resolution]] 1.95Å' scene=''> | |||
[[ | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1yb1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YB1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AOI:ANDROSTERONE'>AOI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yb1 OCA], [https://pdbe.org/1yb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yb1 RCSB], [https://www.ebi.ac.uk/pdbsum/1yb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yb1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DHB11_HUMAN DHB11_HUMAN] Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yb/1yb1_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yb1 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith C]] | ||
[[Category: Bray | [[Category: Bray J]] | ||
[[Category: Bunkoczi | [[Category: Bunkoczi G]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Kavanagh K]] | ||
[[Category: Kavanagh | [[Category: Lukacik P]] | ||
[[Category: Lukacik | [[Category: Ng S]] | ||
[[Category: Ng | [[Category: Oppermann U]] | ||
[[Category: Oppermann | [[Category: Sundstrom M]] | ||
[[Category: Von Delft F]] | |||
[[Category: Sundstrom | |||
[[Category: | |||
Latest revision as of 11:56, 14 February 2024
Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XICrystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI
Structural highlights
FunctionDHB11_HUMAN Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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