1xwf: Difference between revisions
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==K185N mutated S-adenosylhomocysteine hydrolase== | |||
<StructureSection load='1xwf' size='340' side='right'caption='[[1xwf]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1xwf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XWF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XWF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xwf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xwf OCA], [https://pdbe.org/1xwf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xwf RCSB], [https://www.ebi.ac.uk/pdbsum/1xwf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xwf ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SAHH_RAT SAHH_RAT] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xw/1xwf_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xwf ConSurf]. | |||
<div style="clear:both"></div> | |||
=== | ==See Also== | ||
*[[S-adenosylhomocysteine hydrolase|S-adenosylhomocysteine hydrolase]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: | |||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Fujioka | [[Category: Fujioka M]] | ||
[[Category: Gomi | [[Category: Gomi T]] | ||
[[Category: Komoto | [[Category: Komoto J]] | ||
[[Category: Ogawa | [[Category: Ogawa H]] | ||
[[Category: Takata | [[Category: Takata Y]] | ||
[[Category: Takusagawa | [[Category: Takusagawa F]] | ||
[[Category: Yamada | [[Category: Yamada T]] | ||
Latest revision as of 11:53, 14 February 2024
K185N mutated S-adenosylhomocysteine hydrolaseK185N mutated S-adenosylhomocysteine hydrolase
Structural highlights
FunctionSAHH_RAT Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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