1xte: Difference between revisions

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[[Image:1xte.png|left|200px]]


{{STRUCTURE_1xte| PDB=1xte | SCENE= }}
==crystal structure of CISK-PX domain==
<StructureSection load='1xte' size='340' side='right'caption='[[1xte]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1xte]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XTE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XTE FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xte OCA], [https://pdbe.org/1xte PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xte RCSB], [https://www.ebi.ac.uk/pdbsum/1xte PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xte ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SGK3_MOUSE SGK3_MOUSE] Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.<ref>PMID:15774536</ref> <ref>PMID:15774535</ref> <ref>PMID:21113728</ref> <ref>PMID:21451460</ref> <ref>PMID:21865597</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xt/1xte_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xte ConSurf].
<div style="clear:both"></div>


===crystal structure of CISK-PX domain===
==See Also==
 
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
{{ABSTRACT_PUBMED_15126499}}
== References ==
 
<references/>
==About this Structure==
__TOC__
[[1xte]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XTE OCA].
</StructureSection>
 
[[Category: Large Structures]]
==Reference==
<ref group="xtra">PMID:015126499</ref><references group="xtra"/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Joachimiak A]]
[[Category: Joachimiak, A.]]
[[Category: Liu D]]
[[Category: Liu, D]]
[[Category: Songyang Z]]
[[Category: Songyang, Z.]]
[[Category: Xing Y]]
[[Category: Xing, Y.]]
[[Category: Xu W]]
[[Category: Xu, W.]]
[[Category: Zhang R]]
[[Category: Zhang, R.]]
[[Category: Cisk]]
[[Category: Px domain]]
[[Category: Transferase]]

Latest revision as of 11:53, 14 February 2024

crystal structure of CISK-PX domaincrystal structure of CISK-PX domain

Structural highlights

1xte is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.6Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SGK3_MOUSE Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.[1] [2] [3] [4] [5]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Strutz-Seebohm N, Seebohm G, Mack AF, Wagner HJ, Just L, Skutella T, Lang UE, Henke G, Striegel M, Hollmann M, Rouach N, Nicoll RA, McCormick JA, Wang J, Pearce D, Lang F. Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3. J Physiol. 2005 Jun 1;565(Pt 2):381-90. Epub 2005 Mar 17. PMID:15774536 doi:http://dx.doi.org/10.1113/jphysiol.2004.079582
  2. ↑ Strutz-Seebohm N, Seebohm G, Shumilina E, Mack AF, Wagner HJ, Lampert A, Grahammer F, Henke G, Just L, Skutella T, Hollmann M, Lang F. Glucocorticoid adrenal steroids and glucocorticoid-inducible kinase isoforms in the regulation of GluR6 expression. J Physiol. 2005 Jun 1;565(Pt 2):391-401. Epub 2005 Mar 17. PMID:15774535 doi:http://dx.doi.org/10.1113/jphysiol.2004.079624
  3. ↑ Pasham V, Rotte A, Bhandaru M, Eichenmuller M, Frohlich H, Mack AF, Bobbala D, Yang W, Pearce D, Lang F. Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3. J Gastroenterol. 2011 Mar;46(3):305-17. doi: 10.1007/s00535-010-0348-8. Epub 2010, Nov 27. PMID:21113728 doi:http://dx.doi.org/10.1007/s00535-010-0348-8
  4. ↑ Bhandaru M, Kempe DS, Rotte A, Capuano P, Pathare G, Sopjani M, Alesutan I, Tyan L, Huang DY, Siraskar B, Judenhofer MS, Stange G, Pichler BJ, Biber J, Quintanilla-Martinez L, Wagner CA, Pearce D, Foller M, Lang F. Decreased bone density and increased phosphaturia in gene-targeted mice lacking functional serum- and glucocorticoid-inducible kinase 3. Kidney Int. 2011 Jul;80(1):61-7. doi: 10.1038/ki.2011.67. Epub 2011 Mar 30. PMID:21451460 doi:http://dx.doi.org/10.1038/ki.2011.67
  5. ↑ He P, Lee SJ, Lin S, Seidler U, Lang F, Fejes-Toth G, Naray-Fejes-Toth A, Yun CC. Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids. Mol Biol Cell. 2011 Oct;22(20):3812-25. doi: 10.1091/mbc.E11-04-0328. Epub 2011, Aug 24. PMID:21865597 doi:http://dx.doi.org/10.1091/mbc.E11-04-0328

1xte, resolution 1.60Å

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