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[[Image:1xpp.jpg|left|200px]]


{{Structure
==Crystal Structure of TA1416,DNA-directed RNA polymerase subunit L, from Thermoplasma acidophilum==
|PDB= 1xpp |SIZE=350|CAPTION= <scene name='initialview01'>1xpp</scene>, resolution 1.60&Aring;
<StructureSection load='1xpp' size='340' side='right'caption='[[1xpp]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene> and <scene name='pdbligand=ACY:ACETIC ACID'>ACY</scene>
<table><tr><td colspan='2'>[[1xpp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XPP FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
|GENE= rpoL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2303 Thermoplasma acidophilum])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpp OCA], [https://pdbe.org/1xpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xpp RCSB], [https://www.ebi.ac.uk/pdbsum/1xpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xpp ProSAT], [https://www.topsan.org/Proteins/MCSG/1xpp TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RPO11_THEAC RPO11_THEAC] DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_00261]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xp/1xpp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xpp ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of TA1416,DNA-directed RNA polymerase subunit L, from Thermoplasma acidophilum'''
==See Also==
 
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1XPP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPP OCA].
[[Category: Large Structures]]
[[Category: DNA-directed RNA polymerase]]
[[Category: Single protein]]
[[Category: Thermoplasma acidophilum]]
[[Category: Thermoplasma acidophilum]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Evdokimova, E.]]
[[Category: Evdokimova E]]
[[Category: Joachimiak, A.]]
[[Category: Joachimiak A]]
[[Category: Kim, Y.]]
[[Category: Kim Y]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Savchenko A]]
[[Category: Savchenko, A.]]
[[Category: ACY]]
[[Category: FMT]]
[[Category: SCN]]
[[Category: dna-directed rna polymerase]]
[[Category: mcsg]]
[[Category: midwest center for structural genomic]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomic]]
[[Category: thermoplasma acidophilum]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:12:55 2008''

Latest revision as of 11:52, 14 February 2024

Crystal Structure of TA1416,DNA-directed RNA polymerase subunit L, from Thermoplasma acidophilumCrystal Structure of TA1416,DNA-directed RNA polymerase subunit L, from Thermoplasma acidophilum

Structural highlights

1xpp is a 4 chain structure with sequence from Thermoplasma acidophilum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.6Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

RPO11_THEAC DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_00261]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1xpp, resolution 1.60Å

Drag the structure with the mouse to rotate

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