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==Conserved hypothetical protein Pfu-877259-001 from Pyrococcus furiosus== | ==Conserved hypothetical protein Pfu-877259-001 from Pyrococcus furiosus== | ||
<StructureSection load='1xg7' size='340' side='right' caption='[[1xg7]], [[Resolution|resolution]] 1.88Å' scene=''> | <StructureSection load='1xg7' size='340' side='right'caption='[[1xg7]], [[Resolution|resolution]] 1.88Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1xg7]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1xg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XG7 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xg7 OCA], [https://pdbe.org/1xg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xg7 RCSB], [https://www.ebi.ac.uk/pdbsum/1xg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xg7 ProSAT], [https://www.topsan.org/Proteins/SECSG/1xg7 TOPSAN]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/AGOG_PYRFU AGOG_PYRFU] DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xg/1xg7_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xg/1xg7_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xg7 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Adams | [[Category: Pyrococcus furiosus DSM 3638]] | ||
[[Category: Chang | [[Category: Adams MWW]] | ||
[[Category: Chang | [[Category: Arendall III WB]] | ||
[[Category: Chen | [[Category: Chang J]] | ||
[[Category: Chen | [[Category: Chang S-H]] | ||
[[Category: Eneh | [[Category: Chen C-Y]] | ||
[[Category: Habel | [[Category: Chen L]] | ||
[[Category: Hopkins | [[Category: Eneh JC]] | ||
[[Category: Horanyi | [[Category: Habel J]] | ||
[[Category: Hopkins RC]] | |||
[[Category: Horanyi P]] | |||
[[Category: Jenney | [[Category: Jenney Jr FE]] | ||
[[Category: Lee | [[Category: Lee D]] | ||
[[Category: Lee | [[Category: Lee H-S]] | ||
[[Category: Li | [[Category: Li T]] | ||
[[Category: Lin | [[Category: Lin D]] | ||
[[Category: Liu | [[Category: Liu Z-J]] | ||
[[Category: | [[Category: Poole II FL]] | ||
[[Category: Richardson | [[Category: Richardson DC]] | ||
[[Category: | [[Category: Richardson JS]] | ||
[[Category: | [[Category: Rose JP]] | ||
[[Category: Shah | [[Category: Shah C]] | ||
[[Category: Sugar | [[Category: Sugar FJ]] | ||
[[Category: Tempel | [[Category: Tempel W]] | ||
[[Category: Wang | [[Category: Wang B-C]] | ||
[[Category: Xu | [[Category: Xu H]] | ||
[[Category: Yang | [[Category: Yang H]] | ||
[[Category: Zhao | [[Category: Zhao M]] | ||
[[Category: Zhou | [[Category: Zhou W]] | ||
Latest revision as of 11:50, 14 February 2024
Conserved hypothetical protein Pfu-877259-001 from Pyrococcus furiosusConserved hypothetical protein Pfu-877259-001 from Pyrococcus furiosus
Structural highlights
FunctionAGOG_PYRFU DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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