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[[Image:1xcu.gif|left|200px]]<br /><applet load="1xcu" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1xcu, resolution 2.00&Aring;" />
'''oligonucleotid/drug complex'''<br />


==Overview==
==oligonucleotid/drug complex==
The crystal structures of the hexamer duplex d(CGTACG)(2) complexed with the intercalating anthraquinone derivative 1,5-bis[3-(diethylamino)propionamido]anthracene-9,10-dione and the acridine derivative 9-acridinyl tetralysine have been solved at 2.0- and 1.4-A resolution, respectively. In both cases, the drugs adopt multiple orientations within a large DNA cavity constituted by two groups of four approximately coplanar bases. Cations play a pivotal role in the crystal structure. Both complexes crystallise in the presence of Co(2+), Ba(2+) and Na(+) ions. They reveal at least two different types of coordination environments: (1) specific sites for Co(2+) interacting with N7 of guanine; (2) a central ionic site formed by four phosphate groups, which can be occupied by different ions. One more ionic site that is not always occupied by ions is also visible in the electron density map. All of them play a role in the crystal structure.
<StructureSection load='1xcu' size='340' side='right'caption='[[1xcu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1xcu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XCU FirstGlance]. <br>
1XCU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=CO:'>CO</scene>, <scene name='pdbligand=BA:'>BA</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=AN9:'>AN9</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCU OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AN9:1,5-BIS[3-(DIETHYLAMINO)PROPIONAMIDO]ANTHRACENE-9,10-DIONE'>AN9</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xcu OCA], [https://pdbe.org/1xcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xcu RCSB], [https://www.ebi.ac.uk/pdbsum/1xcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xcu ProSAT]</span></td></tr>
Variable role of ions in two drug intercalation complexes of DNA., Valls N, Steiner RA, Wright G, Murshudov GN, Subirana JA, J Biol Inorg Chem. 2005 Aug;10(5):476-82. Epub 2005 Sep 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15926069 15926069]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Murshudov, G N.]]
</StructureSection>
[[Category: Steiner, R A.]]
[[Category: Large Structures]]
[[Category: Subirana, J A.]]
[[Category: Murshudov GN]]
[[Category: Valls, N.]]
[[Category: Steiner RA]]
[[Category: Wright, G.]]
[[Category: Subirana JA]]
[[Category: AN9]]
[[Category: Valls N]]
[[Category: BA]]
[[Category: Wright G]]
[[Category: CO]]
[[Category: NA]]
[[Category: anthraquinone]]
[[Category: co2+]]
[[Category: drug-dna complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:53:24 2008''

Latest revision as of 11:49, 14 February 2024

oligonucleotid/drug complexoligonucleotid/drug complex

Structural highlights

1xcu is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

1xcu, resolution 2.00Å

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