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[[Image:1xbn.gif|left|200px]]


{{Structure
==Crystal structure of a bacterial nitric oxide sensor: an ortholog of mammalian soluble guanylate cyclase heme domain==
|PDB= 1xbn |SIZE=350|CAPTION= <scene name='initialview01'>1xbn</scene>, resolution 2.50&Aring;
<StructureSection load='1xbn' size='340' side='right'caption='[[1xbn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>
<table><tr><td colspan='2'>[[1xbn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis_MB4 Caldanaerobacter subterraneus subsp. tengcongensis MB4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XBN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XBN FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE= Tar4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119072 Thermoanaerobacter tengcongensis])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xbn OCA], [https://pdbe.org/1xbn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xbn RCSB], [https://www.ebi.ac.uk/pdbsum/1xbn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xbn ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xbn OCA], [http://www.ebi.ac.uk/pdbsum/1xbn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xbn RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/Q8RBX6_CALS4 Q8RBX6_CALS4]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/1xbn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xbn ConSurf].
<div style="clear:both"></div>


'''Crystal structure of a bacterial nitric oxide sensor: an ortholog of mammalian soluble guanylate cyclase heme domain'''
==See Also==
 
*[[Chemotaxis protein 3D structures|Chemotaxis protein 3D structures]]
 
*[[Methyl-accepting chemotaxis protein|Methyl-accepting chemotaxis protein]]
==Overview==
__TOC__
Nitric oxide (NO) is extremely toxic to Clostridium botulinum, but its molecular targets are unknown. Here, we identify a heme protein sensor (SONO) that displays femtomolar affinity for NO. The crystal structure of the SONO heme domain reveals a previously undescribed fold and a strategically placed tyrosine residue that modulates heme-nitrosyl coordination. Furthermore, the domain architecture of a SONO ortholog cloned from Chlamydomonas reinhardtii indicates that NO signaling through cyclic guanosine monophosphate arose before the origin of multicellular eukaryotes. Our findings have broad implications for understanding bacterial responses to NO, as well as for the activation of mammalian NO-sensitive guanylyl cyclase.
</StructureSection>
 
[[Category: Caldanaerobacter subterraneus subsp. tengcongensis MB4]]
==About this Structure==
[[Category: Large Structures]]
1XBN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermoanaerobacter_tengcongensis Thermoanaerobacter tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XBN OCA].
[[Category: Nioche P]]
 
[[Category: Raman CS]]
==Reference==
Femtomolar sensitivity of a NO sensor from Clostridium botulinum., Nioche P, Berka V, Vipond J, Minton N, Tsai AL, Raman CS, Science. 2004 Nov 26;306(5701):1550-3. Epub 2004 Oct 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15472039 15472039]
[[Category: Single protein]]
[[Category: Thermoanaerobacter tengcongensis]]
[[Category: Nioche, P.]]
[[Category: Raman, C S.]]
[[Category: cgmp]]
[[Category: heme protein]]
[[Category: nitric oxide]]
[[Category: soluble guanylyl cyclase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:47:24 2008''

Latest revision as of 11:49, 14 February 2024

Crystal structure of a bacterial nitric oxide sensor: an ortholog of mammalian soluble guanylate cyclase heme domainCrystal structure of a bacterial nitric oxide sensor: an ortholog of mammalian soluble guanylate cyclase heme domain

Structural highlights

1xbn is a 1 chain structure with sequence from Caldanaerobacter subterraneus subsp. tengcongensis MB4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q8RBX6_CALS4

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1xbn, resolution 2.50Å

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