1xac: Difference between revisions

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-[[Image:1xac.png|left|200px]]
-{{STRUCTURE_1xac|  PDB=1xac  |  SCENE=  }}
+==CHIMERA ISOPROPYLMALATE DEHYDROGENASE BETWEEN BACILLUS SUBTILIS (M) AND THERMUS THERMOPHILUS (T) FROM N-TERMINAL: 20% T MIDDLE 20% M RESIDUAL 60% T, MUTATED AT S82R. LOW TEMPERATURE (100K) STRUCTURE.==
+<StructureSection load='1xac' size='340' side='right'caption='[[1xac]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-===CHIMERA ISOPROPYLMALATE DEHYDROGENASE BETWEEN BACILLUS SUBTILIS (M) AND THERMUS THERMOPHILUS (T) FROM N-TERMINAL: 20% T MIDDLE 20% M RESIDUAL 60% T, MUTATED AT S82R. LOW TEMPERATURE (100K) STRUCTURE.===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1xac]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XAC FirstGlance]. <br>
-{{ABSTRACT_PUBMED_15299625}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xac OCA], [https://pdbe.org/1xac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xac RCSB], [https://www.ebi.ac.uk/pdbsum/1xac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xac ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[1xac]] is a 1 chain structure of [[Isopropylmalate dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAC OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/LEU3_THET8 LEU3_THET8] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.[HAMAP-Rule:MF_01033]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/1xac_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xac ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Isopropylmalate dehydrogenase|Isopropylmalate dehydrogenase]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:015299625</ref><references group="xtra"/>
+[[Category: Large Structures]]
-[[Category: 3-isopropylmalate dehydrogenase]]
+[[Category: Thermus thermophilus HB8]]
-[[Category: Thermus thermophilus]]
+[[Category: Moriyama H]]
-[[Category: Moriyama, H.]]
+[[Category: Nagata C]]
-[[Category: Nagata, C.]]
+[[Category: Tanaka N]]
-[[Category: Tanaka, N.]]
-[[Category: Chimera]]
-[[Category: Oxidoreductase]]