1vzv: Difference between revisions
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==STRUCTURE OF VARICELLA-ZOSTER VIRUS PROTEASE== | |||
<StructureSection load='1vzv' size='340' side='right'caption='[[1vzv]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1vzv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_3 Human alphaherpesvirus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VZV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vzv OCA], [https://pdbe.org/1vzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vzv RCSB], [https://www.ebi.ac.uk/pdbsum/1vzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vzv ProSAT]</span></td></tr> | |||
== | </table> | ||
[[1vzv]] is a 1 chain structure | == Function == | ||
[https://www.uniprot.org/uniprot/SCAF_VZVD SCAF_VZVD] Capsid scaffolding protein acts as a scaffold protein by binding major capsid protein 40 in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as protein 40 forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein 40. Cleavages products are evicted from the capsid before or during DNA packaging (By similarity). Assemblin is a protease essential for virion assembly in the nucleus. Catalyzes the cleavage of the assembly protein after complete capsid formation. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging (By similarity). Assembly protein plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein 40. Multimerizes in the nucleus such as protein 40 forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vz/1vzv_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vzv ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Virus protease|Virus protease]] | *[[Virus protease 3D structures|Virus protease 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human alphaherpesvirus 3]] | |||
[[Category: Human | [[Category: Large Structures]] | ||
[[Category: Abdel-Meguid | [[Category: Abdel-Meguid SS]] | ||
[[Category: Culp | [[Category: Culp JS]] | ||
[[Category: Debouck | [[Category: Debouck C]] | ||
[[Category: Jason | [[Category: Jason CA]] | ||
[[Category: Qiu | [[Category: Qiu X]] | ||
[[Category: Richardson | [[Category: Richardson SB]] | ||
[[Category: Smith | [[Category: Smith WW]] | ||