1vok: Difference between revisions

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New page: left|200px<br /><applet load="1vok" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vok, resolution 2.1Å" /> '''ARABIDOPSIS THALIANA ...
 
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[[Image:1vok.jpg|left|200px]]<br /><applet load="1vok" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1vok, resolution 2.1&Aring;" />
'''ARABIDOPSIS THALIANA TBP (DIMER)'''<br />


==Overview==
==ARABIDOPSIS THALIANA TBP (DIMER)==
The three-dimensional structure of a TATA box-binding protein (TBP2) from, Arabidopsis thaliana has been refined at 2.1 A resolution. TBPs are, general eukaryotic transcription factors that participate in initiation of, RNA synthesis by all three eukaryotic RNA polymerases. The, carboxy-terminal portion of TBP is a unique DNA-binding motif/protein, fold, adopting a highly symmetric alpha/beta structure that resembles a, molecular saddle with two stirrup-like loops. A ten-stranded, antiparallel, beta-sheet provides a concave surface for recognizing class II nuclear, gene promoters, while the four amphipathic alpha-helices on the convex, surface are available for interaction with other transcription factors., The myriad interactions of TBP2 with components of the transcription, machinery are discussed.
<StructureSection load='1vok' size='340' side='right'caption='[[1vok]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1vok]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VOK FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vok OCA], [https://pdbe.org/1vok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vok RCSB], [https://www.ebi.ac.uk/pdbsum/1vok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vok ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TBP1_ARATH TBP1_ARATH] General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/1vok_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vok ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1VOK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VOK OCA].
*[[TATA-binding protein 3D structures|TATA-binding protein 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
2.1 A resolution refined structure of a TATA box-binding protein (TBP)., Nikolov DB, Burley SK, Nat Struct Biol. 1994 Sep;1(9):621-37. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7634102 7634102]
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Burley, S.K.]]
[[Category: Burley SK]]
[[Category: Nikolov, D.B.]]
[[Category: Nikolov DB]]
[[Category: SO4]]
[[Category: dna binding]]
[[Category: transcription factor]]
[[Category: transcription initiation]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 04:58:25 2007''

Latest revision as of 11:46, 14 February 2024

ARABIDOPSIS THALIANA TBP (DIMER)ARABIDOPSIS THALIANA TBP (DIMER)

Structural highlights

1vok is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TBP1_ARATH General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1vok, resolution 2.10Å

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