1vok: Difference between revisions

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-[[Image:1vok.jpg|left|200px]]
- {{Structure
+==ARABIDOPSIS THALIANA TBP (DIMER)==
-|PDB= 1vok |SIZE=350|CAPTION= <scene name='initialview01'>1vok</scene>, resolution 2.1&Aring;
+<StructureSection load='1vok' size='340' side='right'caption='[[1vok]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
+<table><tr><td colspan='2'>[[1vok]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VOK FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vok OCA], [https://pdbe.org/1vok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vok RCSB], [https://www.ebi.ac.uk/pdbsum/1vok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vok ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TBP1_ARATH TBP1_ARATH] General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/1vok_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vok ConSurf].
+<div style="clear:both"></div>
-'''ARABIDOPSIS THALIANA TBP (DIMER)'''
+==See Also==
+*[[TATA-binding protein 3D structures|TATA-binding protein 3D structures]]
+__TOC__
-==Overview==
+</StructureSection>
-The three-dimensional structure of a TATA box-binding protein (TBP2) from Arabidopsis thaliana has been refined at 2.1 A resolution. TBPs are general eukaryotic transcription factors that participate in initiation of RNA synthesis by all three eukaryotic RNA polymerases. The carboxy-terminal portion of TBP is a unique DNA-binding motif/protein fold, adopting a highly symmetric alpha/beta structure that resembles a molecular saddle with two stirrup-like loops. A ten-stranded, antiparallel beta-sheet provides a concave surface for recognizing class II nuclear gene promoters, while the four amphipathic alpha-helices on the convex surface are available for interaction with other transcription factors. The myriad interactions of TBP2 with components of the transcription machinery are discussed.
-==About this Structure==
-VOK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VOK OCA].
-==Reference==
-.1 A resolution refined structure of a TATA box-binding protein (TBP)., Nikolov DB, Burley SK, Nat Struct Biol. 1994 Sep;1(9):621-37. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7634102 7634102]
 [[Category: Arabidopsis thaliana]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Burley, S K.]]
+[[Category: Burley SK]]
-[[Category: Nikolov, D B.]]
+[[Category: Nikolov DB]]
-[[Category: SO4]]
-[[Category: dna binding]]
-[[Category: transcription factor]]
-[[Category: transcription initiation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:47:43 2008''