1u5f: Difference between revisions

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[[Image:1u5f.png|left|200px]]


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==Crystal Structure of the PH Domain of SKAP-Hom with 8 Vector-derived N-terminal Residues==
The line below this paragraph, containing "STRUCTURE_1u5f", creates the "Structure Box" on the page.
<StructureSection load='1u5f' size='340' side='right'caption='[[1u5f]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1u5f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5F FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_1u5f|  PDB=1u5f  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5f OCA], [https://pdbe.org/1u5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5f RCSB], [https://www.ebi.ac.uk/pdbsum/1u5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5f ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of the PH Domain of SKAP-Hom with 8 Vector-derived N-terminal Residues===
== Function ==
 
[https://www.uniprot.org/uniprot/SKAP2_MOUSE SKAP2_MOUSE] May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.<ref>PMID:11063873</ref> <ref>PMID:15894167</ref> <ref>PMID:16135797</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
1U5F is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5F OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u5f ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Eck, M J.]]
[[Category: Eck MJ]]
[[Category: Neel, B G.]]
[[Category: Neel BG]]
[[Category: Swanson, K D.]]
[[Category: Swanson KD]]
[[Category: Tang, Y.]]
[[Category: Tang Y]]
[[Category: Artefactual dimerization induced by vector-derived sequence]]
[[Category: Ph domain of skap-hom]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:05:02 2009''

Latest revision as of 11:43, 14 February 2024

Crystal Structure of the PH Domain of SKAP-Hom with 8 Vector-derived N-terminal ResiduesCrystal Structure of the PH Domain of SKAP-Hom with 8 Vector-derived N-terminal Residues

Structural highlights

1u5f is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SKAP2_MOUSE May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Curtis DJ, Jane SM, Hilton DJ, Dougherty L, Bodine DM, Begley CG. Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest. Exp Hematol. 2000 Nov;28(11):1250-9. PMID:11063873
  2. ↑ Bourette RP, Therier J, Mouchiroud G. Macrophage colony-stimulating factor receptor induces tyrosine phosphorylation of SKAP55R adaptor and its association with actin. Cell Signal. 2005 Aug;17(8):941-9. Epub 2005 Jan 20. PMID:15894167 doi:http://dx.doi.org/S0898-6568(04)00262-1
  3. ↑ Togni M, Swanson KD, Reimann S, Kliche S, Pearce AC, Simeoni L, Reinhold D, Wienands J, Neel BG, Schraven B, Gerber A. Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM. Mol Cell Biol. 2005 Sep;25(18):8052-63. PMID:16135797 doi:http://dx.doi.org/25/18/8052

1u5f, resolution 1.90Å

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