1u5f: Difference between revisions

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[[Image:1u5f.png|left|200px]]


{{STRUCTURE_1u5f|  PDB=1u5f  |  SCENE=  }}
==Crystal Structure of the PH Domain of SKAP-Hom with 8 Vector-derived N-terminal Residues==
 
<StructureSection load='1u5f' size='340' side='right'caption='[[1u5f]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
===Crystal Structure of the PH Domain of SKAP-Hom with 8 Vector-derived N-terminal Residues===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1u5f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5F FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[1u5f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5F OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5f OCA], [https://pdbe.org/1u5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5f RCSB], [https://www.ebi.ac.uk/pdbsum/1u5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SKAP2_MOUSE SKAP2_MOUSE] May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.<ref>PMID:11063873</ref> <ref>PMID:15894167</ref> <ref>PMID:16135797</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u5f ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Eck, M J.]]
[[Category: Eck MJ]]
[[Category: Neel, B G.]]
[[Category: Neel BG]]
[[Category: Swanson, K D.]]
[[Category: Swanson KD]]
[[Category: Tang, Y.]]
[[Category: Tang Y]]
[[Category: Artefactual dimerization induced by vector-derived sequence]]
[[Category: Ph domain of skap-hom]]
[[Category: Signaling protein]]

Latest revision as of 11:43, 14 February 2024

Crystal Structure of the PH Domain of SKAP-Hom with 8 Vector-derived N-terminal ResiduesCrystal Structure of the PH Domain of SKAP-Hom with 8 Vector-derived N-terminal Residues

Structural highlights

1u5f is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SKAP2_MOUSE May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Curtis DJ, Jane SM, Hilton DJ, Dougherty L, Bodine DM, Begley CG. Adaptor protein SKAP55R is associated with myeloid differentiation and growth arrest. Exp Hematol. 2000 Nov;28(11):1250-9. PMID:11063873
  2. ↑ Bourette RP, Therier J, Mouchiroud G. Macrophage colony-stimulating factor receptor induces tyrosine phosphorylation of SKAP55R adaptor and its association with actin. Cell Signal. 2005 Aug;17(8):941-9. Epub 2005 Jan 20. PMID:15894167 doi:http://dx.doi.org/S0898-6568(04)00262-1
  3. ↑ Togni M, Swanson KD, Reimann S, Kliche S, Pearce AC, Simeoni L, Reinhold D, Wienands J, Neel BG, Schraven B, Gerber A. Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM. Mol Cell Biol. 2005 Sep;25(18):8052-63. PMID:16135797 doi:http://dx.doi.org/25/18/8052

1u5f, resolution 1.90Å

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