1u3p: Difference between revisions

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-{{Seed}}
-[[Image:1u3p.png|left|200px]]
-<!--
+==IspF native==
-The line below this paragraph, containing "STRUCTURE_1u3p", creates the "Structure Box" on the page.
+<StructureSection load='1u3p' size='340' side='right'caption='[[1u3p]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1u3p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3P FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_1u3p|  PDB=1u3p  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3p OCA], [https://pdbe.org/1u3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3p RCSB], [https://www.ebi.ac.uk/pdbsum/1u3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3p ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ISPF_ECOLI ISPF_ECOLI] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). Also converts 4-diphosphocytidyl-2-C-methyl-D-erythritol into 2-C-methyl-D-erythritol 3,4-cyclophosphate and CMP.<ref>PMID:10694574</ref> <ref>PMID:22839733</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3p_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u3p ConSurf].
+<div style="clear:both"></div>
-===IspF native===
+==See Also==
+*[[MECDP synthase 3D structures|MECDP synthase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_11829504}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 11829504 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_11829504}}
-==About this Structure==
-U3P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3P OCA].
-==Reference==
-Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids., Steinbacher S, Kaiser J, Wungsintaweekul J, Hecht S, Eisenreich W, Gerhardt S, Bacher A, Rohdich F, J Mol Biol. 2002 Feb 8;316(1):79-88. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11829504 11829504]
-[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
 [[Category: Escherichia coli]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Bacher, A.]]
+[[Category: Bacher A]]
-[[Category: Eisenreich, W.]]
+[[Category: Eisenreich W]]
-[[Category: Gerhardt, S.]]
+[[Category: Gerhardt S]]
-[[Category: Hecht, S.]]
+[[Category: Hecht S]]
-[[Category: Kaiser, J.]]
+[[Category: Kaiser J]]
-[[Category: Rohdich, F.]]
+[[Category: Rohdich F]]
-[[Category: Steinbacher, S.]]
+[[Category: Steinbacher S]]
-[[Category: Wungsintaweekul, J.]]
+[[Category: Wungsintaweekul J]]
-[[Category: Lyase]]
-[[Category: Mep pathway]]
-[[Category: Terpene biosynthesis]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:04:41 2008''