1u3g: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(11 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1u3g.jpg|left|200px]]


<!--
==Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)==
The line below this paragraph, containing "STRUCTURE_1u3g", creates the "Structure Box" on the page.
<StructureSection load='1u3g' size='340' side='right'caption='[[1u3g]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1u3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3G FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=THF:5-HYDROXYMETHYLENE-6-HYDROFOLIC+ACID'>THF</scene></td></tr>
{{STRUCTURE_1u3g|  PDB=1u3g  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3g OCA], [https://pdbe.org/1u3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3g RCSB], [https://www.ebi.ac.uk/pdbsum/1u3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3g ProSAT], [https://www.topsan.org/Proteins/BSGC/1u3g TOPSAN]</span></td></tr>
 
</table>
'''Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)'''
== Function ==
 
[https://www.uniprot.org/uniprot/MTHFS_MYCPN MTHFS_MYCPN] Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.<ref>PMID:16104022</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
1U3G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3G OCA].  
Check<jmol>
 
  <jmolCheckbox>
==Reference==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3g_consurf.spt"</scriptWhenChecked>
Crystal structure of methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087) at 2.2 A resolution., Chen S, Shin DH, Pufan R, Kim R, Kim SH, Proteins. 2004 Sep 1;56(4):839-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15281135 15281135]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: 5-formyltetrahydrofolate cyclo-ligase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Mycoplasma pneumoniae]]
  </jmolCheckbox>
[[Category: Single protein]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u3g ConSurf].
[[Category: BSGC, Berkeley Structural Genomics Center.]]
<div style="clear:both"></div>
[[Category: Chen, S.]]
== References ==
[[Category: Kim, R.]]
<references/>
[[Category: Kim, S H.]]
__TOC__
[[Category: Proudfoot, M.]]
</StructureSection>
[[Category: Yakunin, A F.]]
[[Category: Large Structures]]
[[Category: 5,10-methenyltetrahydrofolate synthetase]]
[[Category: Atp binding]]
[[Category: Berkeley structural genomics center]]
[[Category: Bsgc structure funded by nih]]
[[Category: Ligase]]
[[Category: Mthf]]
[[Category: Mycoplasma pneumoniae]]
[[Category: Mycoplasma pneumoniae]]
[[Category: Protein structure initiative]]
[[Category: Chen S]]
[[Category: Psi]]
[[Category: Kim R]]
[[Category: Structural genomic]]
[[Category: Kim S-H]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:42:49 2008''
[[Category: Proudfoot M]]
[[Category: Yakunin AF]]

Latest revision as of 11:43, 14 February 2024

Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)

Structural highlights

1u3g is a 1 chain structure with sequence from Mycoplasma pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

MTHFS_MYCPN Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Chen S, Yakunin AF, Proudfoot M, Kim R, Kim SH. Structural and functional characterization of a 5,10-methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087). Proteins. 2005 Nov 1;61(2):433-43. PMID:16104022 doi:10.1002/prot.20591

1u3g, resolution 2.50Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=1u3g&oldid=4055810"