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<StructureSection load='1u3g' size='340' side='right'caption='[[1u3g]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1u3g' size='340' side='right'caption='[[1u3g]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1u3g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"filterable_agent_of_primary_atypical_pneumonia"_eaton_et_al._1944 "filterable agent of primary atypical pneumonia" eaton et al. 1944]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U3G FirstGlance]. <br>
<table><tr><td colspan='2'>[[1u3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3G FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=THF:5-HYDROXYMETHYLENE-6-HYDROFOLIC+ACID'>THF</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u3f|1u3f]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=THF:5-HYDROXYMETHYLENE-6-HYDROFOLIC+ACID'>THF</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-formyltetrahydrofolate_cyclo-ligase 5-formyltetrahydrofolate cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.2 6.3.3.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3g OCA], [https://pdbe.org/1u3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3g RCSB], [https://www.ebi.ac.uk/pdbsum/1u3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3g ProSAT], [https://www.topsan.org/Proteins/BSGC/1u3g TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3g OCA], [http://pdbe.org/1u3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1u3g RCSB], [http://www.ebi.ac.uk/pdbsum/1u3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3g ProSAT], [http://www.topsan.org/Proteins/BSGC/1u3g TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MTHFS_MYCPN MTHFS_MYCPN] Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.<ref>PMID:16104022</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u3g ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u3g ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Filterable agent of primary atypical pneumonia eaton et al. 1944]]
[[Category: 5-formyltetrahydrofolate cyclo-ligase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Chen, S]]
[[Category: Kim, R]]
[[Category: Kim, S H]]
[[Category: Proudfoot, M]]
[[Category: Yakunin, A F]]
[[Category: 10-methenyltetrahydrofolate synthetase]]
[[Category: Atp binding]]
[[Category: Bsgc structure funded by nih]]
[[Category: Ligase]]
[[Category: Mthf]]
[[Category: Mycoplasma pneumoniae]]
[[Category: Mycoplasma pneumoniae]]
[[Category: PSI, Protein structure initiative]]
[[Category: Chen S]]
[[Category: Kim R]]
[[Category: Kim S-H]]
[[Category: Proudfoot M]]
[[Category: Yakunin AF]]

Latest revision as of 11:43, 14 February 2024

Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)

Structural highlights

1u3g is a 1 chain structure with sequence from Mycoplasma pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

MTHFS_MYCPN Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Chen S, Yakunin AF, Proudfoot M, Kim R, Kim SH. Structural and functional characterization of a 5,10-methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087). Proteins. 2005 Nov 1;61(2):433-43. PMID:16104022 doi:10.1002/prot.20591

1u3g, resolution 2.50Å

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