1u3g: Difference between revisions

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{{STRUCTURE_1u3g|  PDB=1u3g  |  SCENE=  }}
==Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)==
 
<StructureSection load='1u3g' size='340' side='right'caption='[[1u3g]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1u3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U3G FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=THF:5-HYDROXYMETHYLENE-6-HYDROFOLIC+ACID'>THF</scene></td></tr>
[[1u3g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycoplasma_pneumoniae Mycoplasma pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3G OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3g OCA], [https://pdbe.org/1u3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u3g RCSB], [https://www.ebi.ac.uk/pdbsum/1u3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u3g ProSAT], [https://www.topsan.org/Proteins/BSGC/1u3g TOPSAN]</span></td></tr>
 
</table>
==Reference==
== Function ==
<ref group="xtra">PMID:015281135</ref><references group="xtra"/>
[https://www.uniprot.org/uniprot/MTHFS_MYCPN MTHFS_MYCPN] Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.<ref>PMID:16104022</ref>
[[Category: 5-formyltetrahydrofolate cyclo-ligase]]
== Evolutionary Conservation ==
[[Category: Mycoplasma pneumoniae]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: BSGC, Berkeley Structural Genomics Center.]]
Check<jmol>
[[Category: Chen, S.]]
  <jmolCheckbox>
[[Category: Kim, R.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u3g_consurf.spt"</scriptWhenChecked>
[[Category: Kim, S H.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Proudfoot, M.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Yakunin, A F.]]
  </jmolCheckbox>
[[Category: 10-methenyltetrahydrofolate synthetase]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u3g ConSurf].
[[Category: Atp binding]]
<div style="clear:both"></div>
[[Category: Berkeley structural genomics center]]
== References ==
[[Category: Bsgc structure funded by nih]]
<references/>
[[Category: Ligase]]
__TOC__
[[Category: Mthf]]
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycoplasma pneumoniae]]
[[Category: Mycoplasma pneumoniae]]
[[Category: Protein structure initiative]]
[[Category: Chen S]]
[[Category: Psi]]
[[Category: Kim R]]
[[Category: Structural genomic]]
[[Category: Kim S-H]]
[[Category: Proudfoot M]]
[[Category: Yakunin AF]]

Latest revision as of 11:43, 14 February 2024

Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)Structural and Functional Characterization of a 5,10-Methenyltetrahydrofolate Synthetase from Mycoplasma pneumoniae (GI: 13508087)

Structural highlights

1u3g is a 1 chain structure with sequence from Mycoplasma pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

MTHFS_MYCPN Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Chen S, Yakunin AF, Proudfoot M, Kim R, Kim SH. Structural and functional characterization of a 5,10-methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087). Proteins. 2005 Nov 1;61(2):433-43. PMID:16104022 doi:10.1002/prot.20591

1u3g, resolution 2.50Å

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