1tsx: Difference between revisions

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[[Image:1tsx.png|left|200px]]


{{STRUCTURE_1tsx|  PDB=1tsx  |  SCENE=  }}
==THYMIDYLATE SYNTHASE R179E MUTANT==
 
<StructureSection load='1tsx' size='340' side='right'caption='[[1tsx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===THYMIDYLATE SYNTHASE R179E MUTANT===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1tsx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TSX FirstGlance]. <br>
{{ABSTRACT_PUBMED_9053905}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tsx OCA], [https://pdbe.org/1tsx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tsx RCSB], [https://www.ebi.ac.uk/pdbsum/1tsx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tsx ProSAT]</span></td></tr>
[[1tsx]] is a 1 chain structure of [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSX OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ts/1tsx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tsx ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Thymidylate synthase|Thymidylate synthase]]
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:009053905</ref><ref group="xtra">PMID:011829503</ref><references group="xtra"/>
[[Category: Lacticaseibacillus casei]]
[[Category: Lactobacillus casei]]
[[Category: Large Structures]]
[[Category: Thymidylate synthase]]
[[Category: Finer-Moore J]]
[[Category: Finer-Moore, J.]]
[[Category: Stroud RM]]
[[Category: Stroud, R M.]]
[[Category: Methyltransferase]]
[[Category: Nucleotide biosynthesis]]
[[Category: Transferase]]

Latest revision as of 11:41, 14 February 2024

THYMIDYLATE SYNTHASE R179E MUTANTTHYMIDYLATE SYNTHASE R179E MUTANT

Structural highlights

1tsx is a 1 chain structure with sequence from Lacticaseibacillus casei. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TYSY_LACCA Provides the sole de novo source of dTMP for DNA biosynthesis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1tsx, resolution 2.50Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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