1tsx: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1tsx.png|left|200px]]
-{{STRUCTURE_1tsx|  PDB=1tsx  |  SCENE=  }}
+==THYMIDYLATE SYNTHASE R179E MUTANT==
+<StructureSection load='1tsx' size='340' side='right'caption='[[1tsx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-===THYMIDYLATE SYNTHASE R179E MUTANT===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1tsx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TSX FirstGlance]. <br>
-{{ABSTRACT_PUBMED_9053905}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tsx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tsx OCA], [https://pdbe.org/1tsx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tsx RCSB], [https://www.ebi.ac.uk/pdbsum/1tsx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tsx ProSAT]</span></td></tr>
-[[1tsx]] is a 1 chain structure of [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TSX OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ts/1tsx_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tsx ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Thymidylate synthase|Thymidylate synthase]]
+*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:009053905</ref><ref group="xtra">PMID:011829503</ref><references group="xtra"/>
+[[Category: Lacticaseibacillus casei]]
-[[Category: Lactobacillus casei]]
+[[Category: Large Structures]]
-[[Category: Thymidylate synthase]]
+[[Category: Finer-Moore J]]
-[[Category: Finer-Moore, J.]]
+[[Category: Stroud RM]]
-[[Category: Stroud, R M.]]
-[[Category: Methyltransferase]]
-[[Category: Nucleotide biosynthesis]]
-[[Category: Transferase]]