1tgv: Difference between revisions

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New page: left|200px<br /><applet load="1tgv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tgv, resolution 2.20Å" /> '''Structure of E. coli...
 
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[[Image:1tgv.gif|left|200px]]<br /><applet load="1tgv" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1tgv, resolution 2.20&Aring;" />
'''Structure of E. coli Uridine Phosphorylase complexed with 5-Fluorouridine and sulfate'''<br />


==About this Structure==
==Structure of E. coli Uridine Phosphorylase complexed with 5-Fluorouridine and sulfate==
1TGV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with SO4, K and 5UD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Uridine_phosphorylase Uridine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.3 2.4.2.3] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TGV OCA].  
<StructureSection load='1tgv' size='340' side='right'caption='[[1tgv]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1tgv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TGV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5UD:5-FLUOROURIDINE'>5UD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tgv OCA], [https://pdbe.org/1tgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tgv RCSB], [https://www.ebi.ac.uk/pdbsum/1tgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tgv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UDP_ECOLI UDP_ECOLI] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tg/1tgv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tgv ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]]
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Uridine phosphorylase]]
[[Category: Begley TP]]
[[Category: Begley, T.P.]]
[[Category: Bu W]]
[[Category: Bu, W.]]
[[Category: Ealick SE]]
[[Category: Ealick, S.E.]]
[[Category: Sanders JM]]
[[Category: Sanders, J.M.]]
[[Category: Settembre EC]]
[[Category: Settembre, E.C.]]
[[Category: 5UD]]
[[Category: K]]
[[Category: SO4]]
[[Category: uridine phosphorylase; pyrimidine nucleoside phosphorylase; uridine salvage; 5-fluorouridine]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:15:12 2007''

Latest revision as of 11:39, 14 February 2024

Structure of E. coli Uridine Phosphorylase complexed with 5-Fluorouridine and sulfateStructure of E. coli Uridine Phosphorylase complexed with 5-Fluorouridine and sulfate

Structural highlights

1tgv is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

UDP_ECOLI Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1tgv, resolution 2.20Å

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