1tgv: Difference between revisions

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-[[Image:1tgv.gif|left|200px]]<br /><applet load="1tgv" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="1tgv, resolution 2.20&Aring;" />
-'''Structure of E. coli Uridine Phosphorylase complexed with 5-Fluorouridine and sulfate'''<br />
-==About this Structure==
+==Structure of E. coli Uridine Phosphorylase complexed with 5-Fluorouridine and sulfate==
-TGV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=K:'>K</scene> and <scene name='pdbligand=5UD:'>5UD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Uridine_phosphorylase Uridine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.3 2.4.2.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGV OCA].
+<StructureSection load='1tgv' size='340' side='right'caption='[[1tgv]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1tgv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TGV FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5UD:5-FLUOROURIDINE'>5UD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tgv OCA], [https://pdbe.org/1tgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tgv RCSB], [https://www.ebi.ac.uk/pdbsum/1tgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tgv ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/UDP_ECOLI UDP_ECOLI] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tg/1tgv_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tgv ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]]
+__TOC__
+</StructureSection>
 [[Category: Escherichia coli]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Uridine phosphorylase]]
+[[Category: Begley TP]]
-[[Category: Begley, T P.]]
+[[Category: Bu W]]
-[[Category: Bu, W.]]
+[[Category: Ealick SE]]
-[[Category: Ealick, S E.]]
+[[Category: Sanders JM]]
-[[Category: Sanders, J M.]]
+[[Category: Settembre EC]]
-[[Category: Settembre, E C.]]
-[[Category: 5UD]]
-[[Category: K]]
-[[Category: SO4]]
-[[Category: uridine phosphorylase; pyrimidine nucleoside phosphorylase; uridine salvage; 5-fluorouridine]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:13:27 2008''