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[[Image:1tfk.png|left|200px]]


{{STRUCTURE_1tfk|  PDB=1tfk  |  SCENE=  }}
==Ribonuclease from Escherichia coli complexed with its inhibtor protein==
 
<StructureSection load='1tfk' size='340' side='right'caption='[[1tfk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
===Ribonuclease from Escherichia coli complexed with its inhibtor protein===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1tfk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TFK FirstGlance]. <br>
{{ABSTRACT_PUBMED_15336558}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tfk OCA], [https://pdbe.org/1tfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tfk RCSB], [https://www.ebi.ac.uk/pdbsum/1tfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tfk ProSAT]</span></td></tr>
[[1tfk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFK OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/CEAD_ECOLX CEAD_ECOLX] Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.  Colicin D inhibits protein synthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tf/1tfk_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tfk ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Colicin|Colicin]]
*[[Colicin 3D structures|Colicin 3D structures]]
*[[Colicin Immunity Protein|Colicin Immunity Protein]]
*[[Colicin immunity protein 3D structures|Colicin immunity protein 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:015336558</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Hidaka, M.]]
[[Category: Large Structures]]
[[Category: Kezuka, Y.]]
[[Category: Hidaka M]]
[[Category: Masaki, H.]]
[[Category: Kezuka Y]]
[[Category: Nakanishi, K.]]
[[Category: Masaki H]]
[[Category: Nonaka, T.]]
[[Category: Nakanishi K]]
[[Category: Ogawa, T.]]
[[Category: Nonaka T]]
[[Category: Ohsawa, K.]]
[[Category: Ogawa T]]
[[Category: Takahashi, K.]]
[[Category: Ohsawa K]]
[[Category: Yajima, S.]]
[[Category: Takahashi K]]
[[Category: Protein-protein complex]]
[[Category: Yajima S]]
[[Category: Toxin-toxin inhibitor complex]]

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