1tfj: Difference between revisions

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[[Image:1tfj.png|left|200px]]


{{STRUCTURE_1tfj|  PDB=1tfj  |  SCENE=  }}
==Crystal structure of Bovine Glycolipid transfer protein in complex with a fatty acid==
 
<StructureSection load='1tfj' size='340' side='right'caption='[[1tfj]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
===Crystal structure of Bovine Glycolipid transfer protein in complex with a fatty acid===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1tfj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TFJ FirstGlance]. <br>
{{ABSTRACT_PUBMED_16309699}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DKA:DECANOIC+ACID'>DKA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tfj OCA], [https://pdbe.org/1tfj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tfj RCSB], [https://www.ebi.ac.uk/pdbsum/1tfj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tfj ProSAT]</span></td></tr>
[[1tfj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFJ OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/GLTP_BOVIN GLTP_BOVIN] Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.<ref>PMID:10671554</ref> <ref>PMID:16309699</ref>
<ref group="xtra">PMID:016309699</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tf/1tfj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tfj ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Airenne, T T.]]
[[Category: Large Structures]]
[[Category: Kidron, H.]]
[[Category: Airenne TT]]
[[Category: Mattjus, P.]]
[[Category: Kidron H]]
[[Category: Nymalm, Y.]]
[[Category: Mattjus P]]
[[Category: Salminen, T A.]]
[[Category: Nymalm Y]]
[[Category: West, G.]]
[[Category: Salminen TA]]
[[Category: Glycolipid]]
[[Category: West G]]
[[Category: Lipid transport]]

Latest revision as of 11:39, 14 February 2024

Crystal structure of Bovine Glycolipid transfer protein in complex with a fatty acidCrystal structure of Bovine Glycolipid transfer protein in complex with a fatty acid

Structural highlights

1tfj is a 1 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.61Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLTP_BOVIN Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Lin X, Mattjus P, Pike HM, Windebank AJ, Brown RE. Cloning and expression of glycolipid transfer protein from bovine and porcine brain. J Biol Chem. 2000 Feb 18;275(7):5104-10. PMID:10671554
  2. ↑ Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA. Structural evidence for adaptive ligand binding of glycolipid transfer protein. J Mol Biol. 2006 Jan 13;355(2):224-36. Epub 2005 Nov 8. PMID:16309699 doi:10.1016/j.jmb.2005.10.031

1tfj, resolution 1.61Å

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OCA
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