1t73: Difference between revisions
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==Crystal structure of the androgen receptor ligand binding domain in complex with a FxxFF motif== | |||
<StructureSection load='1t73' size='340' side='right'caption='[[1t73]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1t73]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pan_troglodytes Pan troglodytes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T73 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHT:5-ALPHA-DIHYDROTESTOSTERONE'>DHT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t73 OCA], [https://pdbe.org/1t73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t73 RCSB], [https://www.ebi.ac.uk/pdbsum/1t73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t73 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ANDR_PANTR ANDR_PANTR] Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2.Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t7/1t73_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t73 ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[Androgen receptor 3D structures|Androgen receptor 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[ | |||
< | |||
[[Category: Pan troglodytes]] | [[Category: Pan troglodytes]] | ||
[[Category: Buehrer | [[Category: Buehrer BM]] | ||
[[Category: Fletterick | [[Category: Fletterick RJ]] | ||
[[Category: Gron | [[Category: Gron H]] | ||
[[Category: Hur | [[Category: Hur E]] | ||
[[Category: Payne | [[Category: Payne ES]] | ||
[[Category: Pfaff | [[Category: Pfaff SJ]] | ||
Latest revision as of 11:36, 14 February 2024
Crystal structure of the androgen receptor ligand binding domain in complex with a FxxFF motifCrystal structure of the androgen receptor ligand binding domain in complex with a FxxFF motif
Structural highlights
FunctionANDR_PANTR Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2.Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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