1t4j: Difference between revisions

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[[Image:1t4j.png|left|200px]]


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==Allosteric Inhibition of Protein Tyrosine Phosphatase 1B==
The line below this paragraph, containing "STRUCTURE_1t4j", creates the "Structure Box" on the page.
<StructureSection load='1t4j' size='340' side='right'caption='[[1t4j]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1t4j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T4J FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FRJ:3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFURAN-6-SULFONIC+ACID+[4-(THIAZOL-2-YLSULFAMOYL)-PHENYL]-AMIDE'>FRJ</scene></td></tr>
{{STRUCTURE_1t4j| PDB=1t4j |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t4j OCA], [https://pdbe.org/1t4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t4j RCSB], [https://www.ebi.ac.uk/pdbsum/1t4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t4j ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t4/1t4j_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t4j ConSurf].
<div style="clear:both"></div>


===Allosteric Inhibition of Protein Tyrosine Phosphatase 1B===
==See Also==
 
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
 
== References ==
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<references/>
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</StructureSection>
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{{ABSTRACT_PUBMED_15258570}}
 
==About this Structure==
1T4J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T4J OCA].
 
==Reference==
Allosteric inhibition of protein tyrosine phosphatase 1B., Wiesmann C, Barr KJ, Kung J, Zhu J, Erlanson DA, Shen W, Fahr BJ, Zhong M, Taylor L, Randal M, McDowell RS, Hansen SK, Nat Struct Mol Biol. 2004 Aug;11(8):730-7. Epub 2004 Jul 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15258570 15258570]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Barr KJ]]
[[Category: Barr, K J.]]
[[Category: Fahr BJ]]
[[Category: Fahr, B J.]]
[[Category: Hansen SK]]
[[Category: Hansen, S K.]]
[[Category: Kung J]]
[[Category: Kung, J.]]
[[Category: McDowell RS]]
[[Category: McDowell, R S.]]
[[Category: Randal M]]
[[Category: Randal, M.]]
[[Category: Shen W]]
[[Category: Shen, W.]]
[[Category: Taylor L]]
[[Category: Taylor, L.]]
[[Category: Wiesmann C]]
[[Category: Wiesmann, C.]]
[[Category: Zhong M]]
[[Category: Zhong, M.]]
[[Category: Zhu J]]
[[Category: Zhu, J.]]
[[Category: Allosteric inhibition protein tyrosine phosphatase 1b]]
 
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