1t3a: Difference between revisions

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[[Image:1t3a.png|left|200px]]


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==Crystal structure of Clostridium botulinum neurotoxin type E catalytic domain==
The line below this paragraph, containing "STRUCTURE_1t3a", creates the "Structure Box" on the page.
<StructureSection load='1t3a' size='340' side='right'caption='[[1t3a]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1t3a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3A FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_1t3a| PDB=1t3a |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3a OCA], [https://pdbe.org/1t3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3a RCSB], [https://www.ebi.ac.uk/pdbsum/1t3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BXE_CLOBO BXE_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 180-Arg-|-Ile-181 bond in SNAP-25.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t3/1t3a_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t3a ConSurf].
<div style="clear:both"></div>


===Crystal structure of Clostridium botulinum neurotoxin type E catalytic domain===
==See Also==
 
*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
 
__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_15157097}}
 
==About this Structure==
1T3A is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3A OCA].
 
==Reference==
<ref group="xtra">PMID:15157097</ref><references group="xtra"/>
[[Category: Bontoxilysin]]
[[Category: Clostridium botulinum]]
[[Category: Clostridium botulinum]]
[[Category: Agarwal, R.]]
[[Category: Large Structures]]
[[Category: Binz, T.]]
[[Category: Agarwal R]]
[[Category: Eswaramoorthy, S.]]
[[Category: Binz T]]
[[Category: Kumaran, D.]]
[[Category: Eswaramoorthy S]]
[[Category: Swaminathan, S.]]
[[Category: Kumaran D]]
[[Category: Catalytic domain]]
[[Category: Swaminathan S]]
[[Category: Clostridium botulinum]]
[[Category: Light chain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:15:53 2009''

Latest revision as of 11:35, 14 February 2024

Crystal structure of Clostridium botulinum neurotoxin type E catalytic domainCrystal structure of Clostridium botulinum neurotoxin type E catalytic domain

Structural highlights

1t3a is a 2 chain structure with sequence from Clostridium botulinum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.16Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BXE_CLOBO Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 180-Arg-|-Ile-181 bond in SNAP-25.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1t3a, resolution 2.16Å

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