1sji: Difference between revisions

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-[[Image:1sji.png|left|200px]]
-{{STRUCTURE_1sji|  PDB=1sji  |  SCENE=  }}
+==Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization==
+<StructureSection load='1sji' size='340' side='right'caption='[[1sji]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-===Comparing skeletal and cardiac calsequestrin structures and their calcium binding: a proposed mechanism for coupled calcium binding and protein polymerization===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1sji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SJI FirstGlance]. <br>
-{{ABSTRACT_PUBMED_14871888}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sji OCA], [https://pdbe.org/1sji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sji RCSB], [https://www.ebi.ac.uk/pdbsum/1sji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sji ProSAT]</span></td></tr>
-==About this Structure==
+</table>
-[[1sji]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJI OCA].
+== Function ==
+[https://www.uniprot.org/uniprot/CASQ2_CANLF CASQ2_CANLF] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:3427023). Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.<ref>PMID:14871888</ref> <ref>PMID:20302875</ref> <ref>PMID:3427023</ref>
-==Reference==
+== Evolutionary Conservation ==
-<ref group="xtra">PMID:014871888</ref><references group="xtra"/>
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sj/1sji_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sji ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Canis lupus familiaris]]
-[[Category: Dunker, A K.]]
+[[Category: Large Structures]]
-[[Category: Fields, K.]]
+[[Category: Dunker AK]]
-[[Category: Kang, C H.]]
+[[Category: Fields K]]
-[[Category: Kim, E J.]]
+[[Category: Kang CH]]
-[[Category: Park, H J.]]
+[[Category: Kim EJ]]
-[[Category: Park, I Y.]]
+[[Category: Park HJ]]
-[[Category: Youn, B.]]
+[[Category: Park IY]]
-[[Category: Calcium-binding]]
+[[Category: Youn B]]
-[[Category: Calsequestrin]]
-[[Category: Glycoprotein]]
-[[Category: Metal binding protein]]
-[[Category: Muscle protein]]