1sj3: Difference between revisions

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{{Seed}}
[[Image:1sj3.png|left|200px]]


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==Hepatitis Delta Virus Gemonic Ribozyme Precursor, with Mg2+ Bound==
The line below this paragraph, containing "STRUCTURE_1sj3", creates the "Structure Box" on the page.
<StructureSection load='1sj3' size='340' side='right'caption='[[1sj3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1sj3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_delta_virus Hepatitis delta virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SJ3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_1sj3| PDB=1sj3 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sj3 OCA], [https://pdbe.org/1sj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sj3 RCSB], [https://www.ebi.ac.uk/pdbsum/1sj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sj3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sj/1sj3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sj3 ConSurf].
<div style="clear:both"></div>


===Hepatitis Delta Virus Gemonic Ribozyme Precursor, with Mg2+ Bound===
==See Also==
 
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
 
*[[Ribozyme 3D structures|Ribozyme 3D structures]]
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== References ==
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<references/>
(as it appears on PubMed at http://www.pubmed.gov), where 15141216 is the PubMed ID number.
__TOC__
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</StructureSection>
{{ABSTRACT_PUBMED_15141216}}
 
==About this Structure==
1SJ3 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_delta_virus Hepatitis delta virus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJ3 OCA].
 
==Reference==
<ref group="xtra">PMID:15141216</ref><references group="xtra"/>
[[Category: Hepatitis delta virus]]
[[Category: Hepatitis delta virus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Cate, J H.]]
[[Category: Large Structures]]
[[Category: Ding, F.]]
[[Category: Cate JH]]
[[Category: Doudna, J A.]]
[[Category: Ding F]]
[[Category: Ke, A.]]
[[Category: Doudna JA]]
[[Category: Zhou, K.]]
[[Category: Ke A]]
[[Category: Hdv]]
[[Category: Zhou K]]
[[Category: Precurosr]]
[[Category: Ribozyme]]
[[Category: Rna]]
[[Category: U1a]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:06:20 2009''

Latest revision as of 11:31, 14 February 2024

Hepatitis Delta Virus Gemonic Ribozyme Precursor, with Mg2+ BoundHepatitis Delta Virus Gemonic Ribozyme Precursor, with Mg2+ Bound

Structural highlights

1sj3 is a 2 chain structure with sequence from Hepatitis delta virus and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SNRPA_HUMAN Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. RNA. 1998 Dec;4(12):1493-9. PMID:9848648

1sj3, resolution 2.20Å

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