1sj3: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1sj3.png|left|200px]]


{{STRUCTURE_1sj3|  PDB=1sj3  |  SCENE=  }}
==Hepatitis Delta Virus Gemonic Ribozyme Precursor, with Mg2+ Bound==
 
<StructureSection load='1sj3' size='340' side='right'caption='[[1sj3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
===Hepatitis Delta Virus Gemonic Ribozyme Precursor, with Mg2+ Bound===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1sj3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepatitis_delta_virus Hepatitis delta virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SJ3 FirstGlance]. <br>
{{ABSTRACT_PUBMED_15141216}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sj3 OCA], [https://pdbe.org/1sj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sj3 RCSB], [https://www.ebi.ac.uk/pdbsum/1sj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sj3 ProSAT]</span></td></tr>
[[1sj3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_delta_virus Hepatitis delta virus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJ3 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sj/1sj3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sj3 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Nucleoprotein|Nucleoprotein]]
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
*[[Ribozyme|Ribozyme]]
*[[Ribozyme 3D structures|Ribozyme 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:015141216</ref><ref group="xtra">PMID:019178151</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Hepatitis delta virus]]
[[Category: Hepatitis delta virus]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Cate, J H.]]
[[Category: Large Structures]]
[[Category: Ding, F.]]
[[Category: Cate JH]]
[[Category: Doudna, J A.]]
[[Category: Ding F]]
[[Category: Ke, A.]]
[[Category: Doudna JA]]
[[Category: Zhou, K.]]
[[Category: Ke A]]
[[Category: Hdv]]
[[Category: Zhou K]]
[[Category: Precurosr]]
[[Category: Ribozyme]]
[[Category: Rna]]
[[Category: Translation-rna complex]]
[[Category: U1a]]

Latest revision as of 11:31, 14 February 2024

Hepatitis Delta Virus Gemonic Ribozyme Precursor, with Mg2+ BoundHepatitis Delta Virus Gemonic Ribozyme Precursor, with Mg2+ Bound

Structural highlights

1sj3 is a 2 chain structure with sequence from Hepatitis delta virus and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SNRPA_HUMAN Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. RNA. 1998 Dec;4(12):1493-9. PMID:9848648

1sj3, resolution 2.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=1sj3&oldid=4054948"