1sa0: Difference between revisions

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[[Image:1sa0.png|left|200px]]


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==TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX==
The line below this paragraph, containing "STRUCTURE_1sa0", creates the "Structure Box" on the page.
<StructureSection load='1sa0' size='340' side='right'caption='[[1sa0]], [[Resolution|resolution]] 3.58&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1sa0]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SA0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.58&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CN2:2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE'>CN2</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_1sa0|  PDB=1sa0  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sa0 OCA], [https://pdbe.org/1sa0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sa0 RCSB], [https://www.ebi.ac.uk/pdbsum/1sa0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sa0 ProSAT]</span></td></tr>
 
</table>
===TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX===
== Function ==
 
[https://www.uniprot.org/uniprot/TBA1D_BOVIN TBA1D_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sa/1sa0_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_15014504}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[1sa0]] is a 5 chain structure of [[Tubulin]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SA0 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sa0 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Tubulin]]
*[[Stathmin-4 3D structures|Stathmin-4 3D structures]]
 
*[[Tubulin 3D Structures|Tubulin 3D Structures]]
==Reference==
__TOC__
<ref group="xtra">PMID:15014504</ref><references group="xtra"/>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Curmi, P A.]]
[[Category: Curmi PA]]
[[Category: Gigant, B.]]
[[Category: Gigant B]]
[[Category: Jourdain, I.]]
[[Category: Jourdain I]]
[[Category: Knossow, M.]]
[[Category: Knossow M]]
[[Category: Lachkar, S.]]
[[Category: Lachkar S]]
[[Category: Ravelli, R B.]]
[[Category: Ravelli RB]]
[[Category: Sobel, A.]]
[[Category: Sobel A]]
[[Category: Alpha-tubulin]]
[[Category: Beta-tubulin]]
[[Category: Cell cycle]]
[[Category: Colchicine]]
[[Category: Gtpase]]
[[Category: Microtubule podophyllotoxin]]
[[Category: Stathmin]]
[[Category: Tubulin]]

Latest revision as of 11:29, 14 February 2024

TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEXTUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX

Structural highlights

1sa0 is a 5 chain structure with sequence from Bos taurus and Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.58Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TBA1D_BOVIN Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1sa0, resolution 3.58Å

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