1s1s: Difference between revisions

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-[[Image:1s1s.gif|left|200px]]
- {{Structure
+==Crystal Structure of ZipA in complex with indoloquinolizin 10b==
-|PDB= 1s1s |SIZE=350|CAPTION= <scene name='initialview01'>1s1s</scene>, resolution 2.10&Aring;
+<StructureSection load='1s1s' size='340' side='right'caption='[[1s1s]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=WAC:N-{3-[(7AR,12AS,12BS)-7-OXO-1,3,4,6,7,7A,12A,12B-OCTAHYDROINDOLO[2,3-A]QUINOLIZIN-12(2H)-YL]PROPYL}PROPANE-2-SULFONAMIDE'>WAC</scene>
+<table><tr><td colspan='2'>[[1s1s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S1S FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-|GENE= ZIPA, B2412 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WAC:N-{3-[(12BS)-7-OXO-1,3,4,6,7,12B-HEXAHYDROINDOLO[2,3-A]QUINOLIZIN-12(2H)-YL]PROPYL}PROPANE-2-SULFONAMIDE'>WAC</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1s OCA], [https://pdbe.org/1s1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s1s RCSB], [https://www.ebi.ac.uk/pdbsum/1s1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s1s ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ZIPA_ECOLI ZIPA_ECOLI] Interacts directly with the cell division protein FtsZ. Probable receptor for the septal ring structure, may anchor it to the inner-membrane.[HAMAP-Rule:MF_00509]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s1/1s1s_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s1s ConSurf].
+<div style="clear:both"></div>
-'''Crystal Structure of ZipA in complex with indoloquinolizin 10b'''
+==See Also==
+*[[Cell division protein 3D structures|Cell division protein 3D structures]]
+__TOC__
-==Overview==
+</StructureSection>
-The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water.
-==About this Structure==
-S1S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1S OCA].
-==Reference==
-Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction., Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Li Y, Sukhdeo MN, Ding W, Dushin EG, Kenny CH, Moghazeh SL, Petersen PJ, Ruzin AV, Tuckman M, Sutherland AG, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1427-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15006376 15006376]
 [[Category: Escherichia coli]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Ding, W.]]
+[[Category: Ding W]]
-[[Category: Dushin, E G.]]
+[[Category: Dushin EG]]
-[[Category: Foreman, K W.]]
+[[Category: Foreman KW]]
-[[Category: III, T S.Rush.]]
+[[Category: Jennings LD]]
-[[Category: Jennings, L D.]]
+[[Category: Kenny CH]]
-[[Category: Kenny, C H.]]
+[[Category: Li Y]]
-[[Category: Li, Y.]]
+[[Category: Moghazeh SL]]
-[[Category: Moghazeh, S L.]]
+[[Category: Mosyak L]]
-[[Category: Mosyak, L.]]
+[[Category: Petersen PJ]]
-[[Category: Petersen, P J.]]
+[[Category: Rush III TS]]
-[[Category: Ruzin, A V.]]
+[[Category: Ruzin AV]]
-[[Category: Sukhdeo, M N.]]
+[[Category: Sukhdeo MN]]
-[[Category: Sutherland, A G.]]
+[[Category: Sutherland AG]]
-[[Category: Tsao, D H.]]
+[[Category: Tsao DH]]
-[[Category: Tuckman, M.]]
+[[Category: Tuckman M]]
-[[Category: WAC]]
-[[Category: cell cycle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:59:17 2008''