1s1f: Difference between revisions

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{{STRUCTURE_1s1f|  PDB=1s1f  |  SCENE=  }}
==Crystal Structure of Streptomyces Coelicolor A3(2) CYP158A2 from antibiotic biosynthetic pathways==
 
<StructureSection load='1s1f' size='340' side='right'caption='[[1s1f]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
===Crystal Structure of Streptomyces Coelicolor A3(2) CYP158A2 from antibiotic biosynthetic pathways===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1s1f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S1F FirstGlance]. <br>
{{ABSTRACT_PUBMED_15659395}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=PIM:4-PHENYL-1H-IMIDAZOLE'>PIM</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1f OCA], [https://pdbe.org/1s1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s1f RCSB], [https://www.ebi.ac.uk/pdbsum/1s1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s1f ProSAT]</span></td></tr>
[[1s1f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1F OCA].  
</table>
 
== Function ==
==Reference==
[https://www.uniprot.org/uniprot/C1582_STRCO C1582_STRCO] Catalyze oxidative C-C coupling reaction to polymerize flaviolin and form highly conjugated pigments which protect the soil bacterium from deleterious effects of UV irradiation (three isomers of biflaviolin and one triflaviolin).<ref>PMID:15659395</ref> <ref>PMID:16239228</ref>
<ref group="xtra">PMID:015659395</ref><references group="xtra"/>
== Evolutionary Conservation ==
[[Category: Streptomyces coelicolor]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Lamb, D C.]]
Check<jmol>
[[Category: Lei, L.]]
  <jmolCheckbox>
[[Category: Podust, L M.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s1/1s1f_consurf.spt"</scriptWhenChecked>
[[Category: Sundaramoorthy, M.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Waterman, M R.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Zhao, B.]]
  </jmolCheckbox>
[[Category: Antibiotic biosynthesis]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s1f ConSurf].
[[Category: Cyp158a2]]
<div style="clear:both"></div>
[[Category: Cytochrome p450 oxidoreductase]]
== References ==
[[Category: Oxidoreductase]]
<references/>
[[Category: Streptomyce]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Lamb DC]]
[[Category: Lei L]]
[[Category: Podust LM]]
[[Category: Sundaramoorthy M]]
[[Category: Waterman MR]]
[[Category: Zhao B]]

Latest revision as of 11:27, 14 February 2024

Crystal Structure of Streptomyces Coelicolor A3(2) CYP158A2 from antibiotic biosynthetic pathwaysCrystal Structure of Streptomyces Coelicolor A3(2) CYP158A2 from antibiotic biosynthetic pathways

Structural highlights

1s1f is a 1 chain structure with sequence from Streptomyces coelicolor A3(2). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.5Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

C1582_STRCO Catalyze oxidative C-C coupling reaction to polymerize flaviolin and form highly conjugated pigments which protect the soil bacterium from deleterious effects of UV irradiation (three isomers of biflaviolin and one triflaviolin).[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Zhao B, Guengerich FP, Bellamine A, Lamb DC, Izumikawa M, Lei L, Podust LM, Sundaramoorthy M, Kalaitzis JA, Reddy LM, Kelly SL, Moore BS, Stec D, Voehler M, Falck JR, Shimada T, Waterman MR. Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. J Biol Chem. 2005 Mar 25;280(12):11599-607. Epub 2005 Jan 19. PMID:15659395 doi:http://dx.doi.org/10.1074/jbc.M410933200
  2. ↑ Zhao B, Guengerich FP, Voehler M, Waterman MR. Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer. J Biol Chem. 2005 Dec 23;280(51):42188-97. Epub 2005 Oct 20. PMID:16239228 doi:10.1074/jbc.M509220200

1s1f, resolution 1.50Å

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