1rxt: Difference between revisions

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New page: left|200px<br /> <applet load="1rxt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rxt, resolution 3.0Å" /> '''Crystal structure of...
 
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[[Image:1rxt.gif|left|200px]]<br />
<applet load="1rxt" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1rxt, resolution 3.0&Aring;" />
'''Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.'''<br />


==Disease==
==Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.==
Known disease associated with this structure: Thyroid carcinoma, nonmedullary OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606240 606240]]
<StructureSection load='1rxt' size='340' side='right'caption='[[1rxt]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1rxt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RXT FirstGlance]. <br>
1RXT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CO and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RXT OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
[[Category: Glycylpeptide N-tetradecanoyltransferase]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxt OCA], [https://pdbe.org/1rxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rxt RCSB], [https://www.ebi.ac.uk/pdbsum/1rxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rx/1rxt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rxt ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Abeles, R.H.]]
[[Category: Abeles RH]]
[[Category: Frey, G.]]
[[Category: Frey G]]
[[Category: Petsko, G.A.]]
[[Category: Petsko GA]]
[[Category: Ringe, D.]]
[[Category: Ringe D]]
[[Category: Wang, Y.]]
[[Category: Wang Y]]
[[Category: Yang, J.]]
[[Category: Yang J]]
[[Category: CO]]
[[Category: SO4]]
[[Category: alpha-beta structure; unique n-myristoyltransferase fold]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:08:10 2007''

Latest revision as of 11:26, 14 February 2024

Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.

Structural highlights

1rxt is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NMT1_HUMAN Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1rxt, resolution 3.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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