1rxh: Difference between revisions

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-{{Seed}}
-[[Image:1rxh.png|left|200px]]
-<!--
+==Crystal structure of streptavidin mutant L124R (M1) complexed with biotinyl p-nitroanilide (BNI)==
-The line below this paragraph, containing "STRUCTURE_1rxh", creates the "Structure Box" on the page.
+<StructureSection load='1rxh' size='340' side='right'caption='[[1rxh]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1rxh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RXH FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BNI:5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-6-YL)-PENTANOIC+ACID+(4-NITRO-PHENYL)-AMIDE'>BNI</scene></td></tr>
-{{STRUCTURE_1rxh|  PDB=1rxh  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxh OCA], [https://pdbe.org/1rxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rxh RCSB], [https://www.ebi.ac.uk/pdbsum/1rxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxh ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rx/1rxh_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rxh ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of streptavidin mutant L124R (M1) complexed with biotinyl p-nitroanilide (BNI)===
+==See Also==
+*[[Avidin 3D structures|Avidin 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_15079055}}, adds the Publication Abstract to the page
+[[Category: Large Structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 15079055 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_15079055}}
-==About this Structure==
-RXH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXH OCA].
-==Reference==
-Structural elements responsible for conversion of streptavidin to a pseudoenzyme., Eisenberg-Domovich Y, Pazy Y, Nir O, Raboy B, Bayer EA, Wilchek M, Livnah O, Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5916-21. Epub 2004 Apr 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15079055 15079055]
-[[Category: Single protein]]
 [[Category: Streptomyces avidinii]]
-[[Category: Bayer, E A.]]
+[[Category: Bayer EA]]
-[[Category: Eisenberg-Domovich, Y.]]
+[[Category: Eisenberg-Domovich Y]]
-[[Category: Livnah, O.]]
+[[Category: Livnah O]]
-[[Category: Nir, O.]]
+[[Category: Nir O]]
-[[Category: Pazy, Y.]]
+[[Category: Pazy Y]]
-[[Category: Raboy, B.]]
+[[Category: Raboy B]]
-[[Category: Wilchek, M.]]
+[[Category: Wilchek M]]
-[[Category: Avidin]]
-[[Category: Pseudo enzymatic activity]]
-[[Category: Streptavidin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:41:20 2008''